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By Research Areas:	Cancer (333) Cardiovascular Disease (30) Endocrinology (8) Infection (97) Inflammation/Immunology (76) Metabolic Disease (64) Neurological Disease (97)
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762

Inhibitors & Agonists

Screening Libraries

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Peptides

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166

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Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: BCL6

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153006

2,7-Dichlorodihydrofluorescein 2 Publications Verification DCFH2	Others	Others
2,7-Dichlorodihydrofluorescein (DCFH2) is a non-fluorescent probe. 2,7-Dichlorodihydrofluorescein yields the highly fluorescent 2′,7′-dichlorofluorescein (DCF) that can be used for reactive oxygen species measurement .

HY-141721S

2-(((7-Methyloctyl)oxy)carbonyl)benzoic acid-d4	Isotope-Labeled Compounds	Others
2-(((7-Methyloctyl)oxy)carbonyl)benzoic acid-d₄ is the deuterium labeled 2-(((7-Methyloctyl)oxy)carbonyl)benzoic acid[1].

HY-N2371

27-Hydroxycholesterol 2 Publications Verification 27-OHC	Estrogen Receptor/ERR LXR Endogenous Metabolite	Cancer
27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor.

HY-N1681

2,7-Dihydrohomoerysotrine

2,7-Dihydrohomoerysotrine is an alkaloid that can be found in Dysoxylum .

2,7-Dihydrohomoerysotrine
2,7-Dihydrohomoerysotrine is an alkaloid that can be found in Dysoxylum .

HY-N11728

2,7"-Phloroglucinol-6,6'-bieckol	Amylases Glucosidase	Metabolic Disease
2,7"-Phloroglucinol-6,6'-bieckol is an orally active dual α-amylase/α-glucosidase inhibitor with IC₅₀ values of 6.94 μM and 23.35 μM respectively. 2,7"-Phloroglucinol-6, 6'-bieckol alleviates postprandial hyperglycemia in diabetic mice. 2,7"-Phloroglucinol-6,6'-bieckol can be used in diabetes research .

HY-147171

2,7-Bis(alloxycarbonylamino)-9-chloroacridine

Fluorescent Dye Others

2,7-Bis(alloxycarbonylamino)-9-chloroacridine can be used as a fluorescent label.

2,7-Bis(alloxycarbonylamino)-9-chloroacridine	Fluorescent Dye	Others
2,7-Bis(alloxycarbonylamino)-9-chloroacridine can be used as a fluorescent label.

HY-150662S

2-(7-Hydroxycoumarin-4-yl)-propanoic acid methyl ester-d3	Isotope-Labeled Compounds	Others
2-(7-Hydroxycoumarin-4-yl)-propanoic acid methyl ester-d₃ is the deuterium labeled 2-(7-Hydroxycoumarin-4-yl)-propanoic acid methyl ester[1].

HY-N1709

27-p-Coumaroyloxyursolic acid 27-trans-p-Coumaroyloxyursolic acid
27-p-Coumaroyloxyursolic acid (compound 6) is a kind of ulmoidol. 27-p-Coumaroyloxyursolic acid can be isolated from Ilex kudincha. 27-p-Coumaroyloxyursolic acid is an inhibitor of Acyl CoA Cholesteryl Acyl Transferase (ACAT) with an IC50 value of 0.73 μM .

HY-N10200

2,7-Dimethoxy-6-(1-acetoxyethyl)juglone

Others Others

2,7-Dimethoxy-6-(1-acetoxyethyl)juglone is a naphthoquinone derivative found in the fungus Kirschsteiniothelia species .
HY-143367S

27-Hydroxy cholesterol-d6

Isotope-Labeled Compounds Others

27-Hydroxy cholesterol-d₆ is deuterium labeled 27-Hydroxy cholesterol.

2,7-Dimethoxy-6-(1-acetoxyethyl)juglone	Others	Others
2,7-Dimethoxy-6-(1-acetoxyethyl)juglone is a naphthoquinone derivative found in the fungus Kirschsteiniothelia species .

27-Hydroxy cholesterol-d6	Isotope-Labeled Compounds	Others
27-Hydroxy cholesterol-d₆ is deuterium labeled 27-Hydroxy cholesterol.

HY-N10355

27-TBDMS-4-Dehydrowithaferin A	Apoptosis	Cancer
27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent .

HY-N5046

27-O-Acetyl-withaferin A

Others Inflammation/Immunology

27-O-Acetyl-withaferin A is found in Withania aristata .

27-O-Acetyl-withaferin A	Others	Inflammation/Immunology
27-O-Acetyl-withaferin A is found in Withania aristata .

HY-N10354

27-Methyl withaferin A	Apoptosis	Cancer
27-Methyl withaferin A (comppund 26) is an apoptosis inducer with anticancer effects. 27-Methyl withaferin A shows antiproliferative effects against HeLa, A-549 and MCF-7 human tumor cell lines with IC₅₀ values of 3.2 μM, 4.2 μM and 1.4 μM, respectively .

HY-N10351

27-O-(tert-Butyldimethylsilyl)withaferin A	Apoptosis	Cancer
27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells .

HY-139058

23-epi-26-Deoxyactein

27-Deoxyactein
PPAR Metabolic Disease Cancer

23-epi-26-Deoxyactein is a natural and orally active anti-obesity and anti-cancer compound .

23-epi-26-Deoxyactein 27-Deoxyactein	PPAR	Metabolic Disease Cancer
23-epi-26-Deoxyactein is a natural and orally active anti-obesity and anti-cancer compound .

HY-156467

ALK-IN-27	Anaplastic lymphoma kinase (ALK)	Cancer
ALK-IN-27 (compound 1) is a potent ALK inhibitor. ALK-IN-27 shows antitumor activity. ALK-IN-27 has an IC₅₀ of 2.7 nM for Ba/F3 CLIP1-LTK cells .

HY-156467A

ALK-IN-27 TFA	Anaplastic lymphoma kinase (ALK)	Cancer
ALK-IN-27 TFA is the TFA form of ALK-IN-27 (HY-156467). ALK-IN-27 (compound 1) is a potent ALK inhibitor. ALK-IN-27 shows antitumor activity. ALK-IN-27 has an IC₅₀ of 2.7 nM for Ba/F3 CLIP1-LTK cells .

HY-153702

JAK-IN-27	JAK	Cancer
JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC₅₀s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC₅₀=23.7 nM) .

HY-126793

2′,7′-Dichlorofluorescein diacetate 5 Publications Verification DCFH2-DA	Reactive Oxygen Species	Others
2′,7′-Dichlorofluorescein diacetate (DCFH2-DA) is a cell-permeable fluorescent probe. 2′,7′-Dichlorofluorescein diacetate can be used to detect the generation of reactive oxygen intermediates and for assessing the overall oxidative stress in toxicological phenomenon .

HY-107573

KDM2/7-IN-1 1 Publications Verification	Histone Demethylase	Cancer
KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase *KDM2/7* subfamily inhibitor (IC₅₀ values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro .

HY-N10233

6-Ethyl-2,7-dimethoxyjuglone

Endogenous Metabolite Infection

6-Ethyl-2,7-dimethoxyjuglone is a metabolite isolated from freshwater fungi .

*6-Ethyl-2,7-dimethoxyjuglone*	Endogenous Metabolite	Infection
6-Ethyl-2,7-dimethoxyjuglone is a metabolite isolated from freshwater fungi .

HY-W040143

2',7'-Dichlorofluorescein	Reactive Oxygen Species	Cancer
2',7'-Dichlorofluorescein acts as a fluorescent probe (Ex=496 nm and Em=525 nm) for reactive oxygen species (ROS) measurement .

HY-D1078

*5(6)-Carboxy-2',7'-dichlorofluorescein diacetate*	Reactive Oxygen Species	Others
5(6)-Carboxy-2',7'-dichlorofluorescein diacetate is a cell permeant fluorescent indicator. 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate can be used to assess reactive oxygen species (ROS) generation within human neuronal-glial (HNG) cells in primary co-culture

HY-D0050

*5(6)-Carboxy-2',7'-dichlorofluorescein diacetate N-succinimidyl ester*	Fluorescent Dye	Others
5(6)-Carboxy-2',7'-dichlorofluorescein diacetate N-succinimidyl ester (cDCFDASE) is a fluorescent probe. 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate N-succinimidyl ester can be used to evaluate the intracellular pH (pH_in) of living cells at a medium pH (pH_ex) .

HY-N10621

*3,5-Dimethoxy-2,7-phenanthrenediol*	Others	Cancer
3,5-Dimethoxy-2,7-phenanthrenediol (compound 2) is a phenanthrene compound isolated from the roots of Combretum laxum. 3,5-Dimethoxy-2,7-phenanthrenediol is cytotoxic to human cancer cell lines 786-0, MCF-7 and NCI/ADR-RES, with IC₅₀s of 73.26 μM, 118.40 μM and 83.99 μM respectively. 3,5-Dimethoxy-2,7-phenanthrenediol also has free radical scavenging activity with an IC₅₀ of 20.4 μM .

HY-138115

7ß,27-Dihydroxycholesterol 7β, 27-OHC	ROR	Inflammation/Immunology
7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (K_i=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4 ⁺ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1 .

HY-P5286

BMAP-27	Bacterial	Infection Cancer
BMAP-27 is an antimicrobial peptide capable of disrupting the membrane integrity of microorganisms. Due to its membrane permeability, MAP-27 has inhibitory activity against both bacteria and cancer cells .

HY-146647S

Cholesta-3,5-diene-7-one-25,26,26,26,27,27,27-d7	Isotope-Labeled Compounds
Cholesta-3,5-diene-7-one-25,26,26,26,27,27,27-d₇ is the deuterium labeled Cholesta-3,5-diene-7-one-25,26,26,26,27,27,27[1].

HY-P1072

PHM-27 (human)	CGRP Receptor	Cardiovascular Disease Metabolic Disease
PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC₅₀ of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism .

HY-156553

BTK-IN-27	Btk	Inflammation/Immunology Cancer
BTK-IN-27 (example 8) is a BTK inhibitor (IC₅₀: 0.2 nM). BTK-IN-27 shows anti-proliferative activity in TMD8 cells (IC₅₀: < 5 nM). BTK-IN-27 can be used for research of cancer, lymphoma, leukemia and immunological diseases .

HY-19778

(R)-BPO-27 1 Publications Verification	CFTR Autophagy	Inflammation/Immunology
(R)-BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR inhibitor with an IC₅₀ of 4 nM.

HY-19778A

BPO-27 racemate

1 Publications Verification

CFTR Autophagy Inflammation/Immunology

BPO-27 racemate is a potent CFTR inhibitor with an IC₅₀ of 8 nM.

BPO-27 racemate 1 Publications Verification	CFTR Autophagy	Inflammation/Immunology
BPO-27 racemate is a potent CFTR inhibitor with an IC₅₀ of 8 nM.

HY-163457

Antileishmanial agent-27	Aminoacyl-tRNA Synthetase Parasite	Infection
Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs). Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC₅₀ values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties .

HY-161179

TRK-IN-27

Trk Receptor Cancer

TRK-IN-27 (Compound 14q) is a potent TRK inhibitor with good kinase selectivity. TRK-IN-27 effectively inhibits tumor growth .

TRK-IN-27	Trk Receptor	Cancer
TRK-IN-27 (Compound 14q) is a potent TRK inhibitor with good kinase selectivity. TRK-IN-27 effectively inhibits tumor growth .

HY-130851

HS-27	HSP	Cancer
HS-27, a fluorescently-tethered Hsp90 inhibitor, assays surface Hsp90 expression on intact tissue specimens. HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC), that binds to ectopically expressed Hsp90. HS-27 has potential use in a see-and-treat paradigm in breast cancer .

HY-D0194

*5(6)-Carboxy-2',7'-dichlorofluorescein* 1 Publications Verification	Fluorescent Dye	Others
5(6)-Carboxy-2',7'-dichlorofluorescein is an ideal substrate for MRP2 vesicular transport assay, with excellent detection and transport properties .

HY-155408

ALR-27	FLAP	Inflammation/Immunology
ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes .

HY-144817

Tubulin inhibitor 27	Microtubule/Tubulin	Cancer
Tubulin inhibitor 27 (DYT-1) is a tubulin polymerisation inhibitor with an IC₅₀ of 25.6 µM. Tubulin inhibitor 27 shows anti-angiogenesis and antitumor activities .

HY-P0139

Gap 27 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment .

HY-155069

Antiproliferative agent-27	Apoptosis	Cancer
Antiproliferative agent-27 (compound 11) is an antiproliferative agent that significantly reduces the number of tumor cell colonies and induces apoptosis. Antiproliferative agent-27 has the potential to be used in the study of cancer .

HY-D0323

Vat Black 27

Fluorescent Dye

Vat Black 27 is a black dye.

Vat Black 27	Fluorescent Dye
Vat Black 27 is a black dye.

HY-147883

Antitubercular agent-27	Bacterial	Infection
Antitubercular agent-27 (compound 1) is a potent antitubercular agent with an IC₅₀ value of 3.2 µM, an MIC value of 7.8 µM, an IC₉₀ value of 7.0 µM. Antitubercular agent-27 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-27 shows effective intracellular antimycobacterial activity and low cytotoxicity .

HY-148108

AChE-IN-27	Cholinesterase (ChE)	Neurological Disease
AChE-IN-27 (compound 8c) is an AChE inhibitor (IC₅₀=0.19 µM). AChE-IN-27 can be used in studies of neurological diseases such as alzheimer's disease, dementia, ataxia and myasthenia gravis .

HY-155115

LSD1-IN-27	Histone Demethylase PD-1/PD-L1	Cancer
LSD1-IN-27 (Compound 5ac) is a LSD1 inhibitor (IC₅₀: 13 nM). LSD1-IN-27 inhibits the stemness and migration of gastric cancer cells. LSD1-IN-27 also reduces the expression of PD-L1 in BGC-823 and MFC cells. LSD1-IN-27 can enhance T cell immune response in gastric cancer .

HY-W115788S1

Tetradecanoate-d27 potassium

Isotope-Labeled Compounds Others

Tetradecanoate-d₂₇ (potassium) is the deuterium labeled Tetradecanoate[1].
HY-P99057A

Varlilumab (anti-CD27)

TNF Receptor Cancer

Varlilumab (anti-CD27) is a first-in-class human IgG1 anti-CD27 monoclonal antibody. Varlilumab has an anti-tumor activity .

Tetradecanoate-d27 potassium	Isotope-Labeled Compounds	Others
Tetradecanoate-d₂₇ (potassium) is the deuterium labeled Tetradecanoate[1].

Varlilumab (anti-CD27)	TNF Receptor	Cancer
Varlilumab (anti-CD27) is a first-in-class human IgG1 anti-CD27 monoclonal antibody. Varlilumab has an anti-tumor activity .

HY-160002

MAO-B-IN-27	Monoamine Oxidase	Neurological Disease
MAO-B-IN-27 (Compound 12c) is a monoamine oxidase B (MAO-B) inhibitor. MAO-B-IN-27 has potent and selective MAO-B inhibitory effect for hMAO-B with an IC₅₀ values of 8.9 nM. MAO-B-IN-27 can be used for the research of parkinson's disease (PD) .

HY-B0370

Tolnaftate

1 Publications Verification

NP-27
Fungal Infection

Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent. .

HY-161120

NLRP3-IN-27	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-27 is a selective NLRP3 inhibitor with a IC₅₀ value of 0.55 μM. NLRP3-IN-27 can be used in the study of inflammation and immunity .

HY-P3418

CKLF1-C27	CCR ERK	Inflammation/Immunology
CKLF1-C27, a C-terminal peptide of CKLF1, binds to CCR4 receptor and activates ERK1/2 pathway. CKLF1-C27 can abrogate the effect of CKLF1 on cells by competing for CCR4 receptor. CKLF1-C27 shows great effect on promoting proliferation on HUVECs. CKLF1-C27 has the potential for psoriasis research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2371

27-Hydroxycholesterol 2 Publications Verification 27-OHC	Structural Classification Natural Products Classification of Application Fields Source classification Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Cancer	Estrogen Receptor/ERR LXR Endogenous Metabolite
27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor.

HY-N11728

2,7"-Phloroglucinol-6,6'-bieckol	Structural Classification Microorganisms Source classification Phenols Polyphenols	Amylases Glucosidase
2,7"-Phloroglucinol-6,6'-bieckol is an orally active dual α-amylase/α-glucosidase inhibitor with IC₅₀ values of 6.94 μM and 23.35 μM respectively. 2,7"-Phloroglucinol-6, 6'-bieckol alleviates postprandial hyperglycemia in diabetic mice. 2,7"-Phloroglucinol-6,6'-bieckol can be used in diabetes research .

HY-N10200

2,7-Dimethoxy-6-(1-acetoxyethyl)juglone	Quinones Monophenols Microorganisms Classification of Application Fields Anthraquinones Source classification Other Diseases Phenols Disease Research Fields	Others
2,7-Dimethoxy-6-(1-acetoxyethyl)juglone is a naphthoquinone derivative found in the fungus Kirschsteiniothelia species .

HY-N10355

27-TBDMS-4-Dehydrowithaferin A	Quinones Classification of Application Fields Source classification Benzene Quinones Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Apoptosis
27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent .

HY-N5046

27-O-Acetyl-withaferin A	other families Classification of Application Fields Source classification Plants Disease Research Fields Inflammation/Immunology Steroids	Others
27-O-Acetyl-withaferin A is found in Withania aristata .

HY-N10351

27-O-(tert-Butyldimethylsilyl)withaferin A	Classification of Application Fields Source classification Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer	Apoptosis
27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells .

HY-139058

23-epi-26-Deoxyactein 27-Deoxyactein	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Disease Research Fields	PPAR
23-epi-26-Deoxyactein is a natural and orally active anti-obesity and anti-cancer compound .

HY-N10233

*6-Ethyl-2,7-dimethoxyjuglone*	Infection Quinones Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Phenols Naphthalene Quinones Disease Research Fields	Endogenous Metabolite
6-Ethyl-2,7-dimethoxyjuglone is a metabolite isolated from freshwater fungi .

HY-N10621

*3,5-Dimethoxy-2,7-phenanthrenediol*	Structural Classification Combretaceae Phenols Polyphenols Plants Quisqualis indica Linn.	Others
3,5-Dimethoxy-2,7-phenanthrenediol (compound 2) is a phenanthrene compound isolated from the roots of Combretum laxum. 3,5-Dimethoxy-2,7-phenanthrenediol is cytotoxic to human cancer cell lines 786-0, MCF-7 and NCI/ADR-RES, with IC₅₀s of 73.26 μM, 118.40 μM and 83.99 μM respectively. 3,5-Dimethoxy-2,7-phenanthrenediol also has free radical scavenging activity with an IC₅₀ of 20.4 μM .

HY-N10854

Lanosta-7,9(11),23,25(27)-tetraen-26-oic acid, 23,27-epoxy-3-oxo-	Triterpenes Structural Classification Pinaceae Terpenoids Source classification Pseudolarix amabilis (J. Nelson) Rehder Plants	Others
Lanosta-7,9(11),23,25(27)-tetraen-26-oic acid, 23,27-epoxy-3-oxo- is a lanosterane type compound. Lanosta-7,9(11),23,25(27)-tetraen-26-oic acid, 23,27-epoxy-3-oxo- can be isolated from Tu-Jin-Pi (the root bark of Pseudolarix kaempferi) .

HY-N10356

4,27-Dimethyl withaferin A	Source classification Withania somnifera Plants Solanaceae Steroids	Others
4,27-Dimethyl withaferin A is a synthetic analog of withanolide natural products. 4,27-Dimethyl withaferin A has the potential for the research of neurodegenerative diseases (extracted from patent WO2015077780A1) .

HY-N10698

*(2E,4E)-8-Hydroxy-2,7-dimethyl-decadien-(2,4)-disaeure-(1,10)-dioic acid*	Apocynaceae Structural Classification Ketones, Aldehydes, Acids Source classification Plants Cynanchum bungei Decne.	Others
(2E,4E)-8-Hydroxy-2,7-dimethyl-decadien-(2,4)-disaeure-(1,10)-dioic acid is a nature product that could be isolated form bunge auriculate flower. (2E,4E)-8-Hydroxy-2,7-dimethyl-decadien-(2,4)-disaeure-(1,10)-dioic acid has antioxidant and anti-inflammatory active .

HY-N10888

(22R)-27-Hydroxy-1-oxowitha-2,5,24-trienolide	Structural Classification Datura stramonium L. Source classification Plants Solanaceae Steroids	Others
(22R)-27-Hydroxy-1-oxowitha-2,5,24-trienolide, withanolide, is a natural product. (22R)-27-Hydroxy-1-oxowitha-2,5,24-trienolide can be isolated from the aerial parts of the halophyte Datura stramonium .

HY-N9327

3,11,15,23-Tetraoxo-27ξ-lanosta-8,16-dien-26-oic acid	Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Inflammation/Immunology	Others
3,11,15,23-Tetraoxo-27ξ-lanosta-8,16-dien-26-oic acid, a lanostane-type triterpenoid, is isolated from Antrodia camphorate .

HY-N7164

3-Oxo-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone	Triterpenes Structural Classification Dysoxylum lenticellatum C. Y. Wu ex H. Li Terpenoids Source classification Plants Meliaceae	Others
3-Oxo-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone is a tetranortirucallane-type triterpenoid that can be isolated from Dysoxylum lenticellatum. 3-Oxo-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone has vasodilative effect with diastolic degree of 43.5% at 10 渭g/mL .

HY-N3388

Licoisoflavone B	Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones	Others
Licoisoflavone B is an isoflavone . Licoisoflavone B inhibits lipid peroxidation with an IC₅₀ of 2.7 μM.

HY-13643

Daminozide 2 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Histone Demethylase
Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC₅₀s of 0.55, 1.5 and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested .

HY-N4162

3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone	Triterpenes Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Meliaceae Aphanamixis polystachya (Wall.) R. N. Parker Cancer	Others
3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone is a cytotoxic tirucallane C26 triterpenoid isolated from the stem barks of Aphanamixis grandifolia .

HY-N3573

Chlorahololide D	Structural Classification Chloranthus holostegius (Hand.-Mazz.) Pei et Shan Terpenoids Sesquiterpenes Source classification Chloranthaceae Plants	Potassium Channel
Chlorahololide D is a potent and selective Potassium Channel blocker with an IC₅₀ value of 2.7 μM. Chlorahololide D is a nature product that could be isolated from the whole plant of Chloranthus holostegius .

HY-N12006

*6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone*	Quinones Structural Classification Cassia obtusifolia L. Anthraquinones Source classification Caesalpiniaceae Plants	Glucosidase
6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone (compound 1) is an anthraquinone α-glucosidase inhibitor (IC₅₀:185 μM), which can be isolated from Cassia seeds .

HY-N7507

Sempervirine	Alkaloids Classification of Application Fields Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Indole Alkaloids Cancer	Others
Sempervirine is an indole alkaloid isolated from Gelsemium sempervirens with anti-tumor activities. Sempervirine is against sempervirine-sensitive tumor cells with EC₅₀ values of 2.7 μM, 1.77 μM, and 1.96 μM for Raji, MDA-MB-231 and HeLa cells, respectively .

HY-113273B

Diadenosine pentaphosphate pentaammonium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Diadenosine pentaphosphate pentaammonium is an endogenous vasoactive purine dinucleotide which has been isolated from thrombocytes. Diadenosine polyphosphates (ApnA, n=2–7) have been identified as constituents of secretory vesicles such as in platelets, chromaffin cells, Torpedo synaptic terminals and brain synaptosomes .

HY-113273C

Diadenosine pentaphosphate pentalithium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Diadenosine pentaphosphate pentalithium is an endogenous vasoactive purine dinucleotide which has been isolated from thrombocytes. Diadenosine polyphosphates (ApnA, n=2–7) have been identified as constituents of secretory vesicles such as in platelets, chromaffin cells, Torpedo synaptic terminals and brain synaptosomes .

HY-113273A

Diadenosine pentaphosphate pentasodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Diadenosine pentaphosphate pentasodium is an endogenous vasoactive purine dinucleotide which has been isolated from thrombocytes. Diadenosine polyphosphates (ApnA, n=2–7) have been identified as constituents of secretory vesicles such as in platelets, chromaffin cells, Torpedo synaptic terminals and brain synaptosomes .

HY-W017230

L-Cysteinesulfinic acid monohydrate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	mGluR Endogenous Metabolite
L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

HY-N12482

Callicarboric acid A	Structural Classification Natural Products Labiatae Source classification Callicarpa arborea Roxb. Plants	NOD-like Receptor (NLR)
NLRP3-IN-27 (compound 1) is an inhibitor of NLRP3 with an IC₅₀ value of 0.74 μM. NLRP3 reduces inflammasome-induced pyroptosis in J774A.1 cells. NLRP3-IN-27 can be isolated from Callicarpa arborea Rox .

HY-N12460

Antimicrobial agent-27

Triterpenes Structural Classification Terpenoids Source classification Asclepiadaceae Plants Gymnema sylvestre (Retz.) Schult.

Others

1581276-60-9
HY-N7965

Methyl kakuol

other families Ketones, Aldehydes, Acids Source classification Plants

TRP Channel

Methyl kakuol shows agonistic activity against TRPA1 with an EC₅₀ of 0.27 µM .

HY-N10127

Lepidiline C	Alkaloids other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Others
Lepidiline C shows cytotoxic activity against HL-60 cells with an IC₅₀ of 27.7 μM.

HY-N3500

Ganoderic acid D2	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Ganoderic acid D2 (compound 27) is a triterpenoid isolated from Ganoderma lucidum. Ganoderic acid D2 has anticancer, anti-inflammatory and antioxidative activity .

HY-N7518

Eulophiol	Classification of Application Fields Pholidota yunnanensis Rolfe Orchidaceae Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	Others
Eulophiol shows the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity with an EC₅₀ of 27.7μM. Antioxidant activity .

HY-B0199A

Mycophenolate mofetil hydrochloride RS 61443 hydrochloride; TM-MMF hydrochloride	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Bacterial
Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC₅₀s of 39 nM and 27 nM, respectively.

HY-N10211

Saccharothrixin K	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Bacterial Endogenous Metabolite
Saccharothrixin K, a glycosylated saccharothrixin, shows moderate inhibition against Helicobacter pylori G27, H. pylori 159, and Staphylococcus aureus ATCC25923 with MIC values of 16 μg/mL .

HY-N11031

Z-Antiepilepsirine	Structural Classification Alkaloids Piperidine Alkaloids Piper capense Source classification Piperaceae Plants	Parasite
Z-Antiepilepsirine is an amide alkaloid that can be found in Piper capense L.f. Z-Antiepilepsirine shows antiplasmodial activity with an IC₅₀ value of 27 µM for W2 strain of Plasmodium falciparum .

HY-N10082

Trigoxyphin A	Structural Classification Terpenoids Source classification Diterpenoids Euphorbiaceae Trigonostemon xyphophylloides (Croiz.) L. K. Dai et T. L. Wu Plants	Others
Trigoxyphin A is a oxygenated daphnane-type diterpenoids. Trigoxyphin A exhibites strong cytotoxic activity against HL60 and A549 with IC₅₀s of 0.27 and 7.5 μM, respectively .

HY-N1266

Scutebata B	Structural Classification Terpenoids Labiatae Source classification Derris robusta Diterpenoids Plants	Others
Scutebata B (compound 4) is a neoclerodane diterpenoid iaolated from the whole plant of Scutellaria barbata. Scutebata B has cytotoxic activities with IC₅₀ values of 10.27～28.48 μM .

HY-116038

Kulinone	Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Others
Kulinone has cytotoxic effects against A549, H460 and HGC27 with IC₅₀ values of 6.2 ± 0.1, 7.8 ± 1.2, 5.6 ± 0.2 μg/ml 。

HY-N7916

(-)-Menthone	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Plants Disease Research Fields	Others
(-)-Menthone is a monoterpene component of the essential oil of maturing peppermint. (+)-Neomenthyl-β-d-glucoside is a metabolite of (-)-Menthone .Mortality of two biological forms of Anopheles stephensi(larvae) exposed to about 45 ppm (-)-Menthone is 27.67% and 94.92%.

HY-N10572

Antibacterial synergist 2	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research	Bacterial
Antibacterial synergist 2 (compound 27) is a biofilm inhibitor. Antibacterial synergist 2 shows inhibitory effects to S. enterica, S. aureus, P. aeruginosa and C. albicans. Antibacterial synergist 2 can be used for the research related to biofilm-forming pathogens .

HY-N10294

Epicoccone B	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Disease Research Fields Inflammation/Immunology	HIV
Epicoccone B, firstly reported from C. globosum, exhibits the DPPH free radical scavenging ability with IC₅₀ value of 10.8 μM, and has potent α-glucosidase inhibition with IC₅₀ value of 27.3 μM. Anti-HIV activity .

HY-146036

NADH-IN-1	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
NADH-IN-1 has NADH:ubiquinone oxidoreductase inhibitory activity with an IC₅₀ value of 27 μM. NADH-IN-1 can effectively stimulate glucose uptake in vitro. NADH-IN-1 is readily metabolised by the liver. NADH-IN-1 can be used for researching diabetes .

HY-N9046

Citroside A	Structural Classification Natural Products Source classification Hydrangeaceae Plants	NO Synthase
Citroside A is a megastigmane sesquiterpenoid with cytotoxic and anti-inflammatory activities. Citroside A displays potential effects against NO production with an IC₅₀ of 34.25 μM. Citroside A exhibits pronounced cytotoxicity against SGC-7901 and HeLa cells with IC₅₀ values of 27.52 μM and 29.51 μM, respectively .

HY-N10760

2a,3a,23-Trihydroxyurs-12,20(30)-dien-28-oic acid	Triterpenes Structural Classification Juglandaceae Terpenoids Source classification Cyclocarya paliurus (Batal.) Iljinsk. Plants	Others
2a,3a,23-Trihydroxyurs-12,20(30)-dien-28-oic acid (compound 3), a triterpenoid, significantly decreases the level of fibronectin in High-Glucose and TGF-b1 induced HK-2 cells with 27.66 % inhibition rate at 10 μM .

HY-134008

Protoapigenone	Structural Classification Flavonoids Flavones Source classification Plants Macrothelypteris torresiana (Gaud.) Ching Thelypteridaceae	Others
Protoapigenone is an antineoplastic agent isolated from ferns. Protoapigenone has significant inhibitory activity against Hep G2, Hep 3B, MCF-7, A549 and MDAMB-231, with IC₅₀s values of 1.60, 0.23, 0.78, 3.88 and 0.27 μg/mL respectively .

HY-N2735

7,3',4'-Trihydroxy-3-benzyl-2H-chromene	Structural Classification Leguminosae Caesalpinia sappan L. Source classification Phenols Polyphenols Plants	Influenza Virus
7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC₅₀ values of 34.6 µM [H1N1], 39.5 µM [H3N2], and 50.5µM [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus .

HY-N8884

Coelonin	Structural Classification Appendicula reflexa Blume Orchidaceae Source classification Phenols Polyphenols Plants	PTEN Akt NF-κB Interleukin Related TNF Receptor
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits NF-κB activation and *p27Kip1* degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein .

HY-N6712

Thiolutin 2 Publications Verification Acetopyrrothin	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Metabolic Disease Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Antibiotic Endogenous Metabolite Deubiquitinase
Thiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36 . Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation .

HY-30152

Xanthotoxol 2 Publications Verification 8-Hydroxypsoralen	Structural Classification Monophenols other families Source classification Coumarins Phenols Phenylpropanoids Plants Endogenous metabolite	5-HT Receptor Reactive Oxygen Species Endogenous Metabolite
Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC50s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation.

HY-N10678

R-30-Hydroxygambogic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Guttiferae Plants Garcinia hanburyi Hook. f.	Others
R-30-Hydroxygambogic acid is polyprenylated xanthone epimer that can be isolated from gamboges of Garcinia hanburyi. R-30-Hydroxygambogic acid shows cytotoxicities to Human Leukemia K562 cell lines of IC₅₀ values of 2.89 and 1.27 μM for K562/R and K562/S, respectively. R-30-Hydroxygambogic acid can be used for the research of cancer .

HY-W009732

Sinapinic acid 3 Publications Verification Sinapic acid	Monophenols other families Classification of Application Fields Simple Phenylpropanols Source classification Phenols Metabolic Disease Phenylpropanoids Plants Disease Research Fields	HDAC Angiotensin-converting Enzyme (ACE) Reactive Oxygen Species Apoptosis
Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC₅₀ of 2.27 mM , and also inhibits ACE-I activity . Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells . Sinapinic acid shows antioxidant and antidiabetic activities . Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats .

Cat. No.	Product Name	Chemical Structure

HY-141721S

2-(((7-Methyloctyl)oxy)carbonyl)benzoic acid-d4

2-(((7-Methyloctyl)oxy)carbonyl)benzoic acid-d₄ is the deuterium labeled 2-(((7-Methyloctyl)oxy)carbonyl)benzoic acid[1].

HY-150662S

2-(7-Hydroxycoumarin-4-yl)-propanoic acid methyl ester-d3
2-(7-Hydroxycoumarin-4-yl)-propanoic acid methyl ester-d₃ is the deuterium labeled 2-(7-Hydroxycoumarin-4-yl)-propanoic acid methyl ester[1].

HY-143367S

27-Hydroxy cholesterol-d6

27-Hydroxy cholesterol-d₆ is deuterium labeled 27-Hydroxy cholesterol.
HY-146647S

Cholesta-3,5-diene-7-one-25,26,26,26,27,27,27-d7

Cholesta-3,5-diene-7-one-25,26,26,26,27,27,27-d₇ is the deuterium labeled Cholesta-3,5-diene-7-one-25,26,26,26,27,27,27[1].
HY-W115788S1

Tetradecanoate-d27 potassium

Tetradecanoate-d₂₇ (potassium) is the deuterium labeled Tetradecanoate[1].
HY-W004293S

1-Tridecanol-d27

n-Tridecyl Alcohol-d₂₇ is the deuterium labeled 1-Tridecanol[1].
HY-W099586S

Ethyl tetradecanoate-d27

Ethyl tetradecanoate-d₂₇ is the deuterium labeled Ethyl tetradecanoate.
HY-117600S

Tributyl phosphate-D27

Tributyl phosphate-d₂₇ is the deuterium labeled Tributyl phosphate[1].
HY-146788S

7α,27-Dihydroxycholesterol-d6

7α,27-Dihydroxycholesterol-d₆ is deuterium labeled 7α,27-Dihydroxycholesterol.
HY-146790S

7ß,27-Dihydroxycholesterol-d6

7ß,27-Dihydroxycholesterol-d₆ is deuterium labeled 7ß,27-Dihydroxycholesterol.
HY-W110702S

1-Bromotridecane-d27

1-Bromotridecane-d₂₇ is the deuterium labeled 1-Bromotridecane[1].
HY-W653963

Tris(2-butyloxyethyl)phosphate-d27

Tris(2-butyloxyethyl)phosphate-d₂₇ is deuterated labeled Tris(2-butyloxyethyl)phosphate[1].
HY-146895S

14:0 Lyso PC-d27

14:0 Lyso PC-d₂₇ is deuterium labeled 14:0 Lyso PC.

HY-N2041S

Myristic acid-d27 1 Publications Verification
Myristic acid-d₂₇ is the deuterium labeled Myristic acid. Myristic acid is a saturated 14-carbon fatty acid occurring in most animal and vegetable fats, particularly butterfat and coconut, palm, and nutmeg oils.

HY-W004288S

Methyl tetradecanoate-d27
Methyl tetradecanoate-d₂₇ is the deuterium labeled Methyl myristate. Methyl myristate is a saturated fatty acid methyl ester obtained from the esterification of myristic acid. Methyl myristate shows a high melanin induction in B16F10 melanoma[1].

HY-146880S

14:0-14:0 PC-d27

14:0-14:0 PC-d₂₇ is deuterium labeled 14:0-14:0 PC.

HY-112499S

Menaquinone-7-d7

Menaquinone-7-d₇ is the deuterium labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS)[3].

HY-150768S

Guanosine 5'-triphosphate (GTP), ammonium salt-d27

Guanosine 5'-triphosphate (GTP), ammonium salt-d₂₇ is the deuterium labeled Guanosine 5'-triphosphate (GTP), ammonium salt[1].

HY-112499S1

Menaquinone-7-13C6

Menaquinone-7- ¹³C₆ is the ¹³C-labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors[1]. Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins [2]. Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS)[3].

HY-W013061S7

Propane-1,2,3-triyl tripalmitate-d27
Propane-1,2,3-triyl tripalmitate-d₂₇ is the deuterium labeled Propane-1,2,3-triyl tripalmitate. Propane-1,2,3-triyl tripalmitate is an endogenous metabolite.

HY-146881S

1-Myristoyl-2-myristoyl-sn-glycero-3-phosphocholine-d27

1-Myristoyl-2-myristoyl-sn-glycero-3-phosphocholine-d₂₇ is deuterium labeled 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphocholine.
HY-15331

VD3-d6

VD3-d₆ is the deuterium labeled Vitamin D3; tools for determination of Vitamin D3 metabolites in human serum.
HY-B0370S

Tolnaftate (D7)

Tolnaftate-d₇ is the deuterium labeled Tolnaftate. Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent[1][2].

HY-151903S

FGFR2/3-IN-1
FGFR2/3-IN-1 is a potent and selective FGFR2 and FGFR3 (FGFR) inhibitor with IC50s of 1 nM and 0.5 nM, respectively. FGFR2/3-IN-1 displays >40-fold selectivity over FGFR1/FGFR4 and other kinome. FGFR2/3-IN-1 also inhibits FGFR3 V555L and V555M mutants with IC50s of 2.7 nM and 6.1 nM, respectively[1].

HY-B0501S

Danofloxacin-d3 mesylate
Danofloxacin-d₃ (mesylate) is the deuterium labeled Danofloxacin mesylate. Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone antibacterial for veterinary use.

HY-13238S1

Dolutegravir-d3

Dolutegravir-d₃ is the deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2].

HY-13238S2

Dolutegravir-d5

Dolutegravir-d₅ is deuterium labeled Dolutegravir. Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM)[1][2].

HY-150660S

Ercalcidiol-13C5

25-Hydroxyvitamin D2-(20,21,22,26,27- ¹³C₅) solution is the ¹³C labeled 25-Hydroxyvitamin D2[1].
HY-150663S

Calcitriol-13C5

1α,25-Dihydroxyvitamin D3-(23,24,25,26,27- ¹³C₅) solution is the ¹³C labeled 1α,25-Dihydroxyvitamin D3[1].

HY-B0199AS

Mycophenolate Mofetil-d4 hydrochloride
Mycophenolate Mofetil-d₄ hydrochloride is deuterated labeled Mycophenolate mofetil hydrochloride (HY-B0199A). Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC₅₀s of 39 nM and 27 nM, respectively.

HY-50905S

Dovitinib-d8
Dovitinib-d₈ is the deuterium labeled Dovitinib. Dovitinib (CHIR-258) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/FGFR3, VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ, respectively[1][2].

HY-B0121BS

Sumatriptan-d6 succinate
Sumatriptan-d6 succinate is the deuterium labeled Sumatriptan succinate. Sumatriptan succinate is an orally active 5-HT1 receptor agonist with K_is of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for migraine headache research .

HY-10466S

Daclatasvir-d6
Daclatasvir-d₆ is deuterium labeled Daclatasvir. Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 µM and 3.27 µM, respectively[1][2][3].

HY-10466S2

Daclatasvir-d16
Daclatasvir-d₁₆ is deuterium labeled Daclatasvir. Daclatasvir (BMS-790052) is a potent and orally active HCV NS5A protein inhibitor with EC50s range of 9-146 pM for multiple HCV replicon genotypes. Daclatasvir is also a organic anion transporting polypeptide 1B (OATP1B) and OATP1B3 inhibitor with IC50s of 1.5 µM and 3.27 µM, respectively[1][2][3].

HY-17038S1

Agomelatine-d4
Agomelatine-d₄ is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2].

HY-17038S2

Agomelatin-d3
Agomelatin-d₃ is the deuterium labeled Agomelatine. Agomelatine (S-20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively[1]. Agomelatine is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively[2].

HY-14852S

Tafamidis-d3
Tafamidis-d₃ is deuterium labeled Tafamidis. Tafamidis is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis[1].

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