CDK7-IN-27
CDK7-IN-27 (Compound 37) is a selective inhibitor for cyclin-dependent kinase 7 (CDK7), with Ki of 3 nM. CDK7-IN-27 arrests the cell cycle at G0/G1 phase.
For research use only. We do not sell to patients.
- CAS No.: 3025006-89-4
- Formula: C26H37N7O2
- Molecular Weight:479.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CDK7 3 nM (IC50) |
CDK2 19.4 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| MDA-MB-453 | EC50 |
1.49 μM
Compound: 37
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Antiproliferative activity against human MDA-MB-453 cells assessed as reduction in cell viability incubated for 5 days by CCK-8 assay
Antiproliferative activity against human MDA-MB-453 cells assessed as reduction in cell viability incubated for 5 days by CCK-8 assay
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[PMID: 38586950] |
CDK7-IN-27 (0.04-10 μM, 5 days) inhibits proliferations of MDA-MB-453 cells with EC50 of 1.49 μM[1].
CDK7_IN-27 (1 μM, 24 h) exhibits good metabolic stability in liver microsomes in mouse and human , with a half-time of 38.5 min and 34.1 min[1].
CDK7_IN-27 (0-1 μM, 24 h) suppresses the phosphorylation of retinoblastoma (Rb) protein through CDK7 inhibition, and thus arrests the cell cycle at G0/G1 phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-453
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Concentration:0-1 μM
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Incubation Time:24 h
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Result:Inhibited phosphorylation of Rb protein at Ser780, 807/811, and Thr826.
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Cell Line:MDA-MB-453
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Concentration:0.04-10 μM
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Incubation Time:5 days
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Result:Suppressed the cancer cell proliferation.
Chemical Information
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CAS No. 3025006-89-4
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Molecular Weight 479.62
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Formula C26H37N7O2
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SMILES
CC(C1=C2N=C3N=C(N2N=C1)NCC4=CC=CC=C4OC[C@H](CCCC5(CN3)CCNCC5)O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK7-IN-27 Related Classifications
HY-162416 Related Classifications
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