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Cat. No.: HY-128403

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BTK inhibitor 8

BTK inhibitor 8 (Compound 27) is a Btk inhibitor with an IC₅₀ of 0.11 nM. BTK inhibitor 8 inhibits Btk activity. BTK inhibitor 8 suppresses B cell activation. BTK inhibitor 8 is applicable to research related to arthritis and asthma.

For research use only. We do not sell to patients.

CAS No.: 2230724-66-8
Formula: C₂₄H₂₃FN₈O₂
Molecular Weight:474.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

BTK inhibitor 8 Chemical Structure

CAS No.: 2230724-66-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

BTK inhibitor 8 potently inhibits BTK with an IC₅₀ of 0.11 nM; it also inhibits B cell activation in hWB with an IC₅₀ of 2 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2230724-66-8
Molecular Weight 474.49
Formula C₂₄H₂₃FN₈O₂
SMILES

O=C(C1=NOC(C(C)(C)C)=N1)NCC2=CC=C(C3=C4C(NC(C5=CN(C)N=C5)=C4)=NC=N3)C=C2F
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Musumeci F, et al. Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors. Expert Opin Ther Pat. 2017 Dec;27(12):1305-1318. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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