KDM6B Protein, Human (Sf9)

KDM6B protein is a histone demethylase targeting "Lys-27" of histone H3, which mainly affects the histone code. Demethylates H3 "Lys-27" to shape the epigenetic landscape. KDM6B Protein, Human (Sf9) is the recombinant human-derived KDM6B protein, expressed by Sf9 insect cells , with tag free. The total length of KDM6B Protein, Human (Sf9) is 496 a.a., .

KDM6B Protein, a histone demethylase with specificity for 'Lys-27' of histone H3, holds a central position in the intricate histone code, as evidenced by multiple studies. This enzyme demethylates both trimethylated and dimethylated H3 'Lys-27,' playing a pivotal role in shaping the epigenetic landscape. Beyond its role in histone modification, KDM6B emerges as a key regulator of posterior development, exerting influence on HOX gene expression and contributing to developmental processes. In the context of inflammatory responses, KDM6B plays a vital role in macrophage differentiation during inflammation, impacting gene expression and the differentiation process. Additionally, KDM6B exhibits a demethylase-independent function in chromatin remodeling, serving as a critical link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex, thereby regulating T-box family member-dependent gene expression (By similarity). The multifaceted roles of KDM6B underscore its significance in the dynamic regulation of chromatin structure and gene expression.

Human

Sf9 insect cells

Tag Free

O15054 (D1141-L1636)

/

56.4 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of 50 mM HEPES, pH 7.5, 200 mM NaCl, 20% glycerol.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.