1. Metabolic Enzyme/Protease
    Apoptosis
  2. E1/E2/E3 Enzyme
    Apoptosis
  3. SMIP004

SMIP004 

Cat. No.: HY-15694 Purity: 98.66%
Handling Instructions

SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells.

For research use only. We do not sell to patients.

SMIP004 Chemical Structure

SMIP004 Chemical Structure

CAS No. : 143360-00-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 167 In-stock
Estimated Time of Arrival: December 31
2 mg USD 148 In-stock
Estimated Time of Arrival: December 31
5 mg USD 223 In-stock
Estimated Time of Arrival: December 31
10 mg USD 338 In-stock
Estimated Time of Arrival: December 31
50 mg USD 806 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1290 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells[1][2].

IC50 & Target

SKP2 E3 ligase[1]

In Vitro

SMIP004 decreases the levels of positive cell cycle regulators, upregulates cyclin-dependent kinase inhibitors, and results in G1 arrest, inhibition of colony formation in soft agar, and cell death[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SMIP004 potently inhibits the growth of prostate and breast cancer xenografts in SCID mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

205.30

Formula

C₁₃H₁₉NO

CAS No.

143360-00-3

SMILES

CC1=C(NC(C)=O)C=CC(CCCC)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (487.09 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8709 mL 24.3546 mL 48.7092 mL
5 mM 0.9742 mL 4.8709 mL 9.7418 mL
10 mM 0.4871 mL 2.4355 mL 4.8709 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.18 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SMIP004SMIP 004SMIP-004E1/E2/E3 EnzymeApoptosisE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseInhibitorinhibitorinhibit

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Product Name:
SMIP004
Cat. No.:
HY-15694
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