1. Metabolic Enzyme/Protease
    Apoptosis
  2. E1/E2/E3 Enzyme
    Apoptosis
  3. SMIP004

SMIP004 

Cat. No.: HY-15694 Purity: 98.81%
Handling Instructions

SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells.

For research use only. We do not sell to patients.

SMIP004 Chemical Structure

SMIP004 Chemical Structure

CAS No. : 143360-00-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 245 In-stock
Estimated Time of Arrival: December 31
5 mg USD 223 In-stock
Estimated Time of Arrival: December 31
10 mg USD 338 In-stock
Estimated Time of Arrival: December 31
50 mg USD 806 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1290 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells[1][2].

IC50 & Target

SKP2 E3 ligase[1]

In Vitro

SMIP004 decreases the levels of positive cell cycle regulators, upregulates cyclin-dependent kinase inhibitors, and results in G1 arrest, inhibition of colony formation in soft agar, and cell death[2].

In Vivo

SMIP004 potently inhibits the growth of prostate and breast cancer xenografts in SCID mice[2].

Molecular Weight

205.30

Formula

C₁₃H₁₉NO

CAS No.

143360-00-3

SMILES

CC1=C(NC(C)=O)C=CC(CCCC)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (487.09 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8709 mL 24.3546 mL 48.7092 mL
5 mM 0.9742 mL 4.8709 mL 9.7418 mL
10 mM 0.4871 mL 2.4355 mL 4.8709 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.18 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SMIP004
Cat. No.:
HY-15694
Quantity: