1. Apoptosis
  2. Apoptosis
  3. SMIP004

SMIP004 

Cat. No.: HY-15694 Purity: 98.81%
Handling Instructions

SMIP004 is a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells, it was found to downregulate SKP2 and to stabilize p27.

For research use only. We do not sell to patients.

SMIP004 Chemical Structure

SMIP004 Chemical Structure

CAS No. : 143360-00-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 245 In-stock
Estimated Time of Arrival: December 31
5 mg USD 223 In-stock
Estimated Time of Arrival: December 31
10 mg USD 338 In-stock
Estimated Time of Arrival: December 31
50 mg USD 806 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1290 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 2 publication(s) in Google Scholar

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Description

SMIP004 is a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells, it was found to downregulate SKP2 and to stabilize p27. IC50 Value: 1.09 uM (MTT assay in LNCaP-S14 cells) [1] Target: Apoptosis inducer; SKP2 in vitro: Whereas SMIP012 and 016 were moderately toxic in normal fibroblasts, SMIPs 001 and 004 showed substantial cancer cell specificity being at least five times more potent in LNCaP-S14 than in IMR90 cells , treatment with either MG132 or SMIP004 increased p27 half-life to > 6 h [1]. Both SMIP001 and 004 led to a strong increase in the recruitment of p27 to CDK2, while SMIP001 also slightly increased coprecipitation of p21 (Figure 6c). SMIP004 also reduced the amounts of cyclins E and A retrieved with CDK2. This was paralleled by a marked downregulation of cyclins E and A upon SMIP004 treatment. SMIP004 decreased the levels of positive cell cycle regulators, upregulated cyclin-dependent kinase inhibitors, and resulted in G1 arrest, inhibition of colony formation in soft agar, and cell death [2]. in vivo: SMIP004 potently inhibits the growth of prostate and breast cancer xenografts in mice [2]. Clinical trial:

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (487.09 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8709 mL 24.3546 mL 48.7092 mL
5 mM 0.9742 mL 4.8709 mL 9.7418 mL
10 mM 0.4871 mL 2.4355 mL 4.8709 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.18 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

205.30

Formula

C₁₃H₁₉NO

CAS No.

143360-00-3

SMILES

CC1=C(NC(C)=O)C=CC(CCCC)=C1

Shipping

Room temperature in continental US; may vary elsewhere

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SMIP004
Cat. No.:
HY-15694
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SMIP004

Cat. No.: HY-15694