143360-00-3
143360-00-3
Chemical Structure
SMIP004
- CAS No.: 143360-00-3
- Formula:C13H19NO
- Molecular Weight:205.30
IUPAC Name: N-(4-butyl-2-methylphenyl)acetamide
InChIKey: ZFVMECVBUGMWIX-UHFFFAOYSA-N
SMILES: CC1=C(NC(C)=O)C=CC(CCCC)=C1
Biological Activity: SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SMIP004 | 99.79% | SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.78
HY-124527HET0016 -
Similarity Score 0.77
HY-118167Monoethylglycinexylidide -
Similarity Score 0.77
HY-444813'-Fluoro-4'-methylacetanilide -
Similarity Score 0.75
HY-100775ARFezagepras (Standard) -
Similarity Score 0.74
HY-157260Propylbenzene-(CH2)2-COOH -
Similarity Score 0.74
HY-1014242-Chloro-N-(2-methyl-4-bromophenyl)acetamide -
Similarity Score 0.74
HY-145482W36017 -
Similarity Score 0.74
HY-W077904R2-Chloro-N-(2,6-dimethylphenyl)acetamide (Standard) -
Similarity Score 0.74
HY-W357818Glycinexylidide -
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References
- [1]. Li C, et al. SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination. J Exp Clin Cancer Res. 2019 Feb 13;38(1):76. [Content Brief]
- [2]. Rico-Bautista E, Zhu W, Kitada S, Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via UPR Signaling. Oncotarget. 2013 Jul 14. [Content Brief]
