DS17701585
DS17701585 (Compound 11) is a highly selective, orally active EP300 and CBP inhibitor with IC50 values of 0.040, 0.15, 0.45 and 0.70 µM against CBP, EP300, H3K27 and SOX2. DS17701585 can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2983027-66-1
- Formula: C24H26N4O5S
- Molecular Weight:482.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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H3K27 0.45 μM (IC50) |
SOX2 0.70 μM (IC50) |
EP300 0.04 μM (IC50) |
CBP 0.15 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LK-2 | IC50 |
0.7 μM
Compound: 11; DS17701585
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Inhibition of SOX2 mRNA expression in human LK2 cells incubated for 6 hrs by RT-qPCR analysis
Inhibition of SOX2 mRNA expression in human LK2 cells incubated for 6 hrs by RT-qPCR analysis
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[PMID: 35413416] |
Chemical Information
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CAS No. 2983027-66-1
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Molecular Weight 482.55
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Formula C24H26N4O5S
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SMILES
O=C([C@@H](C1)N(C(C2(C3=CC=C(OC)C=C3)CCCC2)=O)CS1(=O)=O)NC4=CC=CC5=C4C=NN5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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