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Cat. No.: HY-132895

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JNJ-67569762

JNJ-67569762 is a selective BACE1 inhibitor targeting the S3 pocket (IC₅₀ = 2.7 nM).

For research use only. We do not sell to patients.

CAS No.: 2380313-26-6
Formula: C₂₂H₂₂F₄N₄O₅S
Molecular Weight:530.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

JNJ-67569762 Chemical Structure

CAS No.: 2380313-26-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

JNJ-67569762 is a selective BACE1 inhibitor targeting the S3 pocket (IC₅₀ = 2.7 nM).

All Beta-secretase Isoforms :

BACE1
BACE2

Chemical Information

CAS No. 2380313-26-6
Molecular Weight 530.49
Formula C₂₂H₂₂F₄N₄O₅S
SMILES

FC[C@]1(C2=CC(NC(C3=NC=C(OC(F)(O4)F)C4=C3)=O)=CC=C2F)N=C([C@@](C)(CC1)S(CC)(=O)=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rombouts FJR, et al. JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate. J Med Chem. 2021 Oct 14;64(19):14175-14191. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
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References

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JNJ-67569762

All Beta-secretase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JNJ-67569762 Related Classifications

HY-132895 Related Classifications