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Cat. No.: HY-144817

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Tubulin inhibitor 27

Tubulin inhibitor 27 (DYT-1) is a tubulin polymerisation inhibitor with an IC₅₀ of 25.6 μM. Tubulin inhibitor 27 shows anti-angiogenesis and antitumor activities.

For research use only. We do not sell to patients.

CAS No.: 184579-57-5
Formula: C₂₁H₁₉NO₄
Molecular Weight:349.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Tubulin inhibitor 27 Chemical Structure

CAS No.: 184579-57-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Tubulin inhibitor 27 (DYT-1) is a tubulin polymerisation inhibitor with an IC₅₀ of 25.6 μM. Tubulin inhibitor 27 shows anti-angiogenesis and antitumor activities^[1].

IC₅₀ & Target

IC₅₀: 25.6 μM (Tubulin polymerisation)^[1]

In Vitro

Tubulin inhibitor 27 (DYT-1) shows anti-proliferation activity with IC₅₀ values of 6.2 μM and 7.9 μM against K562 and Jurkat, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tubulin inhibitor 27 (DYT-1) shows anti-angiogenesis activity in Zebrafish with an IC₅₀ of 38.4 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 184579-57-5
Molecular Weight 349.38
Formula C₂₁H₁₉NO₄
SMILES

O=C(C1=CC(OC)=C(OC)C(OC)=C1)/C=C/C2=CC=NC3=CC=CC=C23
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yao Y, et al. Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors. J Enzyme Inhib Med Chem. 2022 Dec;37(1):652-665. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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