EGFR-IN-27
EGFR-IN-27 is a potent EGFR inhibitor with IC50s of <50 nM for EGFR Del, L858R, Del/T790M, L858R/T790M, Del/T790M/C797S, and L858R/T790M/C797S, respectively (WO2021249324A1, compound 511).
For research use only. We do not sell to patients.
- CAS No.: 2752328-62-2
- Formula: C35H46N9O2P
- Molecular Weight:655.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
|
EGFRdel19 <50 nM (IC50) |
EGFRL858R <50 nM (IC50) |
EGFRL858R/T790M <50 nM (IC50) |
EGFRdel19 T790M C797S <50 nM (IC50) |
EGFR (C797S/T790M/L858R) <50 nM (IC50) |
EGFRdel19 T790M <50 nM (IC50) |
Chemical Information
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CAS No. 2752328-62-2
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Molecular Weight 655.77
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Formula C35H46N9O2P
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SMILES
O=P(C)(C)C1=C2N=CC=NC2=CC=C1NC3=NC(NC4=C(OC)C=C(N5CCC(CC5)N6CCN(CC6)C)C(CC)=C4)=NC=C3C=C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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