2752328-62-2

EGFR-IN-27 Chemical Structure
2752328-62-2

Chemical Structure

EGFR-IN-27

  • CAS No.: 2752328-62-2
  • Formula:C35H46N9O2P
  • Molecular Weight:655.77

IUPAC Name: (6-((2-((5-ethyl-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-vinylpyrimidin-4-yl)amino)quinoxalin-5-yl)dimethylphosphine oxide

InChIKey: LUKWWQICCRFYBL-UHFFFAOYSA-N

SMILES: O=P(C)(C)C1=C2N=CC=NC2=CC=C1NC3=NC(NC4=C(OC)C=C(N5CCC(CC5)N6CCN(CC6)C)C(CC)=C4)=NC=C3C=C

Biological Activity: EGFR-IN-27 is a potent EGFR inhibitor with IC50s of <50 nM for EGFR Del, L858R, Del/T790M, L858R/T790M, Del/T790M/C797S, and L858R/T790M/C797S, respectively (WO2021249324A1, compound 511)[1].

Cat. No. Product Name Purity Description Pricing
HY-142519 		EGFR-IN-27 EGFR-IN-27 is a potent EGFR inhibitor with IC50s of <50 nM for EGFR Del, L858R, Del/T790M, L858R/T790M, Del/T790M/C797S, and L858R/T790M/C797S, respectively (WO2021249324A1, compound 511).
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