Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27)
Based on 1 Customer Validation
Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27) is a high-affinity, selective VPAC1 receptor antagonist, with IC50 values of 10 nM and 2000 nM for binding to human VPAC1 and VPAC2, respectively. Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27) inhibits VIP-induced VPAC1/Gs/adenylate cyclase signaling with a Ki of 2 nM, and its VPAC1 selectivity is mainly determined by the N-terminal extracellular domain of the receptor. Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27) can be used in studies related to VPAC1 receptor pharmacology, VIP signaling, and the structure and function of class B GPCRs.
For research use only. We do not sell to patients.
- Purity : 98.01%
- CAS No.: 202463-00-1
- Formula: C150H246N44O38
- Molecular Weight:3273.83
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PACAP Receptor Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
VPAC1 receptor 10 nM (IC50) |
VPAC2 receptor 2000 nM (IC50) |
VPAC1 receptor 2 nM (Ki) |
In Vitro
Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27) binds to recombinant human VPAC1 and VPAC2 receptors expressed in CHO cell membranes, with IC50 values of 10 nM and 2000 nM, respectively, and exhibits approximately 200-fold selectivity for VPAC1 over VPAC2[1].
Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27) antagonizes VIP-induced adenylate cyclase activation in CHO cell membranes expressing recombinant human VPAC1, with a Ki of 2 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 202463-00-1
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Appearance Solid
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Molecular Weight 3273.83
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Formula C150H246N44O38
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Color White to off-white
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Sequence
Ac-His-{d-Phe}-Asp-Ala-Val-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Lys-Arg-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-NH2
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Sequence Shortening
Ac-H-{d-Phe}-DAVFTNSYRKVLKRLSARKLLQDIL-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
H2O : 33.33 mg/mL (10.18 mM; adjust pH to 2 with 1 M HCl)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.3055 mL | 1.5273 mL | 3.0545 mL | 7.6363 mL |
| 5 mM | 0.0611 mL | 0.3055 mL | 0.6109 mL | 1.5273 mL | |
| 10 mM | 0.0305 mL | 0.1527 mL | 0.3055 mL | 0.7636 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27) Related Classifications
HY-P4776 Related Classifications
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Keywords
- Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27)
- 202463-00-1
- PACAP Receptor
- Adenylate Cyclase
- N-terminal extracellular domain
- human VPAC1
- adenylate cyclase
- VPAC2 receptor
- CHO cell membranes
- VPAC1 receptor
- wild-type human VPAC1 receptors
- human VPAC2
- chimeric EC1 VPAC2/VPAC1 receptors
- chimeric N-VPAC2/VPAC1 receptors
- Inhibitor
- inhibitor
- inhibit