AL-470
AL-470 is a potent antiviral agent with EC50 values of 0.27, 0.63, and 0.35 µM against HIV-1, HIV-2, and EV-A71, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2671019-15-9
- Formula: C67H57N7O23
- Molecular Weight:1328.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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HIV-1 0.27 μM (EC50) |
HIV-2 0.63 μM (EC50) |
EV-A71 0.35 μM (EC50) |
In Vitro
AL-470 shows antiviral activity against the whole panel of mutant EV-A71 strains: EV-A71 BrCr wt (EC50 = 0.3 ± 0.03 µM), VP1_S184T (EC50 = 2.3 ± 0.6 µM), VP1_P246S (EC50 = 1.9 ± 0.04 µM), VP1_S184T_P246S (EC50 = 2.2 ± 0.08 µM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2671019-15-9
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Molecular Weight 1328.20
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Formula C67H57N7O23
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SMILES
OC(C1=CC(C(O)=O)=CC(C(NC2=CC=CC=C23)=C3C[C@@H](C(O)=O)NC(CCC(CCC(N[C@H](C(O)=O)CC4=C(C5=CC(C(O)=O)=CC(C(O)=O)=C5)NC6=CC=CC=C64)=O)([N+]([O-])=O)CCC(N[C@H](C(O)=O)CC7=C(C8=CC(C(O)=O)=CC(C(O)=O)=C8)NC9=CC=CC=C97)=O)=O)=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AL-470 Related Classifications
HY-146009 Related Classifications
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