PI3K-IN-52
PI3K-IN-52 (compound cis 6g) is a potent inhibitor of PI3K, with IC50 of 0.23 μM in HGC-27 cells. PI3K-IN-52 plays an important role in cancer research[1].
For research use only. We do not sell to patients.
- CAS No.: 3030012-25-7
- Formula: C26H24FN5O3
- Molecular Weight:473.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
2.52 μM
Compound: Cis-6g
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader
|
[PMID: 38377311] |
| HGC-27 | IC50 |
0.23 μM
Compound: Cis-6g
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Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader
|
[PMID: 38377311] |
| MCF7 | IC50 |
11 μM
Compound: Cis-6g
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader
|
[PMID: 38377311] |
| MDA-MB-435 | IC50 |
4.43 μM
Compound: Cis-6g
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Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader
Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader
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[PMID: 38377311] |
| NCI-H1975 | IC50 |
1.2 μM
Compound: Cis-6g
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Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader
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[PMID: 38377311] |
| NCI-H460 | IC50 |
1.75 μM
Compound: Cis-6g
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Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader
Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader
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[PMID: 38377311] |
Chemical Information
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CAS No. 3030012-25-7
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Molecular Weight 473.50
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Formula C26H24FN5O3
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SMILES
CC1=C2C(C(OC3CCOCC3)=CC(C4=CC(/N=N\C5=CC=CC=C5F)=C(N=C4)OC)=C2)=NC=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI3K-IN-52 Related Classifications
HY-161301 Related Classifications
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