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Cat. No.: HY-161301

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PI3K-IN-52

PI3K-IN-52 (compound cis 6g) is a potent inhibitor of PI3K, with IC₅₀ of 0.23 μM in HGC-27 cells. PI3K-IN-52 plays an important role in cancer research_[1].

For research use only. We do not sell to patients.

CAS No.: 3030012-25-7
Formula: C₂₆H₂₄FN₅O₃
Molecular Weight:473.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PI3K-IN-52 Chemical Structure

CAS No.: 3030012-25-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PI3K-IN-52 (compound cis 6g) is a potent inhibitor of PI3K, with IC₅₀ of 0.23 μM in HGC-27 cells. PI3K-IN-52 plays an important role in cancer research_[1].

All PI3K Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	2.52 μM Compound: Cis-6g	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader	[PMID: 38377311]
HGC-27	IC₅₀	0.23 μM Compound: Cis-6g	Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader	[PMID: 38377311]
MCF7	IC₅₀	11 μM Compound: Cis-6g	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader	[PMID: 38377311]
MDA-MB-435	IC₅₀	4.43 μM Compound: Cis-6g	Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader	[PMID: 38377311]
NCI-H1975	IC₅₀	1.2 μM Compound: Cis-6g	Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader	[PMID: 38377311]
NCI-H460	IC₅₀	1.75 μM Compound: Cis-6g	Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth measured after 72 hrs (compound prepared under 365 nm light irradiation for 2 mins every 8 hrs) by Celltiter-Glo reagent based luminescence microplate reader	[PMID: 38377311]

Chemical Information

CAS No. 3030012-25-7
Molecular Weight 473.50
Formula C₂₆H₂₄FN₅O₃
SMILES

CC1=C2C(C(OC3CCOCC3)=CC(C4=CC(/N=N\C5=CC=CC=C5F)=C(N=C4)OC)=C2)=NC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yan Zhang, et al. Design, Synthesis, and Bioevaluation of Novel Reversibly Photoswitchable PI3K Inhibitors Based on Phenylazopyridine Derivatives toward Light-Controlled Cancer Treatment. J Med Chem. 2024 Feb 20. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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