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DI-82 

Cat. No.: HY-136499
Handling Instructions

DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC50app of 27.8 nM and Kiapp of 9.2 nM. DI-82 has antitumor activity.

For research use only. We do not sell to patients.

DI-82 Chemical Structure

DI-82 Chemical Structure

CAS No. : 1638148-50-1

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Description

DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC50app of 27.8 nM and Kiapp of 9.2 nM. DI-82 has antitumor activity[1].

IC50 & Target

IC50app: 27.8 nM (dCK)[1]
Kiapp: 9.2 nM (dCK)[1]

In Vitro

DI-82 (compound 12R) has an IC50 of 3.7 nM in CCRF-CEM acute lymphoblastic leukemia cells[1].
DI-82 (1 μM) has a NADPH-dependent CLint of 22.7 μL/min•mg and a NADPH-dependent T1/2 of 102 mins in a standard microsomal liver clearance assay[1].
DI-82 (200 μM) completely blunts the ability of decitabine to bind human thymidylate synthase (TS)[2].

Molecular Weight

510.65

Formula

C₂₀H₂₆N₆O₄S₃

CAS No.

1638148-50-1

SMILES

NC1=NC(S[[email protected]](C)C(N=C2C(C=C3OCCNS(=O)(C)=O)=CC=C3OC)=C(S2)C)=NC(N)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

DI-82DI82DI 82OthersdeoxycytidinekinasedCKantitumorCCRF-CEMacutelymphoblasticleukemiaNADPHInhibitorinhibitorinhibit

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