PKCiota-IN-1
PKCiota-IN-1 (compound 51) is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.7 nM. PKCiota-IN-1 also inhibits PKC-α and PKC-ε with IC50s of 45 nM and 450 nM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2230052-97-6
- Formula: C25H22FN5O
- Molecular Weight:427.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PKCι 2.7 nM (IC50) |
PKCα 45 nM (IC50) |
PKCε 450 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCCLM3 | GI50 |
6.6 μM
Compound: 51
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Antiproliferative activity against human HCCLM3 cells after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human HCCLM3 cells after 72 hrs by CellTiter-Glo assay
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[PMID: 29688013] |
| Huh-7 | GI50 |
3.3 μM
Compound: 51
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Antiproliferative activity against human HuH7 cells after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human HuH7 cells after 72 hrs by CellTiter-Glo assay
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[PMID: 29688013] |
Chemical Information
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CAS No. 2230052-97-6
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Molecular Weight 427.47
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Formula C25H22FN5O
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SMILES
COC1=CC2=C(CNC(CF)C2)C=C1C3=C4C=C(C5=C6C(NC=C6)=NC=C5)C=CN4N=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PKCiota-IN-1 Related Classifications
HY-122857 Related Classifications
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