1. GPCR/G Protein
  2. P2Y Receptor
  3. NF546

NF546 

Cat. No.: HY-108661
Handling Instructions

NF546 is a selective non-nucleotide P2Y11 agonist with a pEC50 of 6.27. NF546 stimulates release of interleukin-8 from human monocyte-derived dendritic cells.

For research use only. We do not sell to patients.

NF546 Chemical Structure

NF546 Chemical Structure

CAS No. : 1006028-37-0

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Description

NF546 is a selective non-nucleotide P2Y11 agonist with a pEC50 of 6.27. NF546 stimulates release of interleukin-8 from human monocyte-derived dendritic cells[1].

IC50 & Target

pEC50: 6.27 (P2Y11)[1]

In Vitro

NF546 is relatively selective for P2Y11 over P2Y1, P2Y2, P2Y4, P2Y6, P2Y12, P2X1, P2X2, and P2X2-X3. NF546 (100 μM; 24 hours) is equi-efficacious in stimulating TSP-1 release and inhibiting the LPS-induced release of IL-12p70 in human monocyte-derived dendritic cells[1].

Molecular Weight

1180.74

Formula

C₄₇H₄₄N₆Na₄O₁₇P₄

CAS No.

1006028-37-0

SMILES

O=P(O)(O[Na])CC1=C(C=CC(CP(O)(O[Na])=O)=C1)NC(C2=CC(NC(C3=CC(NC(NC4=CC(C(NC5=CC(C(NC6=C(C=C(CP(O)(O[Na])=O)C=C6)CP(O)(O[Na])=O)=O)=CC=C5C)=O)=CC=C4)=O)=CC=C3)=O)=C(C)C=C2)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NF546NF 546NF-546P2Y Receptorselectivenon-nucleotideinterleukinsstimulatesthrombospondin-1secretionLPSInhibitorinhibitorinhibit

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