1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Imetit dihydrobromide

Imetit dihydrobromide (Synonyms: VUF 8325 dihydrobromide; SKF 91105 dihydrobromide)

Cat. No.: HY-101173
Handling Instructions

Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM).

For research use only. We do not sell to patients.

Imetit dihydrobromide Chemical Structure

Imetit dihydrobromide Chemical Structure

CAS No. : 32385-58-3

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Description

Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM)[1][2][3].

IC50 & Target[1]

H3 Receptor

0.3 nM (Ki)

H4 receptor

2.7 nM (Ki)

In Vivo

Imetit dihydrobromide (2.5-10 mg/kg; i.p.) reduces the licking response induced by Apomorphine[4].

Animal Model: Male Sprague-Dawley rats[4]
Dosage: 2.5, 5, 10 mg/kg
Administration: i.p. (30 min before Apomorphine)
Result: Reduced the licking response induced by Apomorphine.
Molecular Weight

332.06

Formula

C₆H₁₂Br₂N₄S

CAS No.

32385-58-3

SMILES

NC(SCCC1=CN=CN1)=N.Br.Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Imetit dihydrobromideVUF 8325 dihydrobromideSKF 91105 dihydrobromideHistamine ReceptorhistaminemimicsshapechangeeosinophilslickingbehaviorInhibitorinhibitorinhibit

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Imetit dihydrobromide
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