32385-58-3
32385-58-3
Chemical Structure
Imetit dihydrobromide
Synonym(s): VUF 8325 dihydrobromide; SKF 91105 dihydrobromide
- CAS No.: 32385-58-3
- Formula:C6H12Br2N4S
- Molecular Weight:332.06
IUPAC Name: 2-(1H-imidazol-5-yl)ethyl carbamimidothioate dihydrobromide
InChIKey: DOBOYMKCRRLTRF-UHFFFAOYSA-N
SMILES: NC(SCCC1=CN=CN1)=N.Br.Br
Biological Activity: Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM)[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Imetit dihydrobromide | 98.16 | Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM). | ||||||||||||||||||||
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References
- [1]. Liu C, et al. Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. [Content Brief]
- [2]. Ling P, et al. Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br J Pharmacol. 2004 May;142(1):161-71. [Content Brief]
- [3]. Garbarg M, et al. S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. J Pharmacol Exp Ther. 1992 Oct;263(1):304-10. [Content Brief]
Keywords
