KDM6B Protein, Human (sf9, His)
KDM6B protein is a histone demethylase targeting "Lys-27" of histone H3, which mainly affects the histone code. Demethylates H3 "Lys-27" to shape the epigenetic landscape. KDM6B Protein, Human (sf9, His) is the recombinant human-derived KDM6B protein, expressed by sf9 insect cells , with N-8*His labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
KDM6B protein is a histone demethylase targeting "Lys-27" of histone H3, which mainly affects the histone code. Demethylates H3 "Lys-27" to shape the epigenetic landscape. KDM6B Protein, Human (sf9, His) is the recombinant human-derived KDM6B protein, expressed by sf9 insect cells , with N-8*His labeled tag.
Background
KDM6B Protein, a histone demethylase with specificity for 'Lys-27' of histone H3, holds a central position in the intricate histone code, as evidenced by multiple studies. This enzyme demethylates both trimethylated and dimethylated H3 'Lys-27,' playing a pivotal role in shaping the epigenetic landscape. Beyond its role in histone modification, KDM6B emerges as a key regulator of posterior development, exerting influence on HOX gene expression and contributing to developmental processes. In the context of inflammatory responses, KDM6B plays a vital role in macrophage differentiation during inflammation, impacting gene expression and the differentiation process. Additionally, KDM6B exhibits a demethylase-independent function in chromatin remodeling, serving as a critical link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex, thereby regulating T-box family member-dependent gene expression (By similarity). The multifaceted roles of KDM6B underscore its significance in the dynamic regulation of chromatin structure and gene expression.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-8*His
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Accession
O15054 (D1141-L1636)
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Gene ID/
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Molecular Construction
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N-term
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8*His
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KDM6B (D1141-L1636)
Accession # O15054 -
C-term
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Protein Length
Partial
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Synonyms
KDM6B; Lysine (K)-Specific Demethylase 6B; Prev. JMJD3; Lysine-Specific Demethylase 6B; KIAA0346; [Histone H3]-Trimethyl-L-Lysine(27) Demethylase; Jumonji Domain Containing 3, Histone Lysine Demethylase; Jumonji Domain Containing 3; [Histone H3]-Trimethyl
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AA Sequence
DVVRASRNAKVKGKFRESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQEEKESEDEESEEPDSTTGTPPSSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTL
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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