(R)-MK-5046
Based on 1 Customer Validation
(R)-MK-5046 is the isomer of MK-5046 (HY-14342), and can be used as an experimental control. MK-5046 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC50 and an EC50 value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity.
For research use only. We do not sell to patients.
- Purity: 98.21%
- CAS No.: 1021736-25-3
- Formula: C20H18F6N4O
- Molecular Weight:444.37
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 1021736-25-3
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Appearance Solid
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Molecular Weight 444.37
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Formula C20H18F6N4O
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Color Light yellow to yellow
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SMILES
O[C@@](CC1=NC(CC2(C(F)(F)F)CC2)=CN1)(C(F)(F)F)C3=CC=C(N4C=CC=N4)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 200 mg/mL (450.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Guan XM, et al. Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist. J Pharmacol Exp Ther. 2011 Feb;336(2):356-364. [Content Brief]
[2]. Sebhat IK, et al. Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity. ACS Med Chem Lett. 2010 Oct 18;2(1):43-47. [Content Brief]
[3]. Ramos-Alvarez I, et al. The Nonpeptide Agonist MK-5046 Functions As an Allosteric Agonist for the Bombesin Receptor Subtype-3. J Pharmacol Exp Ther. 2022 Aug;382(2):66-78. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2504 mL | 11.2519 mL | 22.5038 mL | 56.2594 mL |
| 5 mM | 0.4501 mL | 2.2504 mL | 4.5008 mL | 11.2519 mL | |
| 10 mM | 0.2250 mL | 1.1252 mL | 2.2504 mL | 5.6259 mL | |
| 15 mM | 0.1500 mL | 0.7501 mL | 1.5003 mL | 3.7506 mL | |
| 20 mM | 0.1125 mL | 0.5626 mL | 1.1252 mL | 2.8130 mL | |
| 25 mM | 0.0900 mL | 0.4501 mL | 0.9002 mL | 2.2504 mL | |
| 30 mM | 0.0750 mL | 0.3751 mL | 0.7501 mL | 1.8753 mL | |
| 40 mM | 0.0563 mL | 0.2813 mL | 0.5626 mL | 1.4065 mL | |
| 50 mM | 0.0450 mL | 0.2250 mL | 0.4501 mL | 1.1252 mL | |
| 60 mM | 0.0375 mL | 0.1875 mL | 0.3751 mL | 0.9377 mL | |
| 80 mM | 0.0281 mL | 0.1406 mL | 0.2813 mL | 0.7032 mL | |
| 100 mM | 0.0225 mL | 0.1125 mL | 0.2250 mL | 0.5626 mL |
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