1. Cell Cycle/DNA Damage
  2. PPAR

DG172 dihydrochloride 

Cat. No.: HY-19737A Purity: 99.91%
Handling Instructions

DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC50 of 27 nM.

For research use only. We do not sell to patients.
DG172 dihydrochloride Chemical Structure

DG172 dihydrochloride Chemical Structure

CAS No. : 1361504-77-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
5 mg USD 72 In-stock
10 mg USD 120 In-stock
50 mg USD 468 In-stock
100 mg USD 804 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • References

Description

DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC50 of 27 nM.

IC50 & Target[1]

PPARβ/δ

27 nM (IC50)

In Vitro

DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC50 of 27 nM. DG172 enhances transcriptional corepressor recruitment, and down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC50, 9.5 nM)[1]. DG172 (1 µM) promotes the differentiation of dendritic cells (DCs) from GM-CSF-induced mouse bone marrow cells (BMCs) and reduces Ly6b+/Gr1+ granulocytic cells. DG172 has effects on the transcriptome of GM-CSF differentiated BMCs from WT and Ppard null mice, and acts at a specific stage of GM-CSF-induced differentiation[2]. DG172 (0.1, 1.0 µM) dose-dependently promotes proliferation of TM4 cells. DG172 reduces expression of claudin-11 in TM4 cells[3].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.1967 mL 10.9837 mL 21.9674 mL
5 mM 0.4393 mL 2.1967 mL 4.3935 mL
10 mM 0.2197 mL 1.0984 mL 2.1967 mL
Please refer to the solubility information to select the appropriate solvent.
Cell Assay
[3]

The xCELLigence system is used for determining the changes in real time cell proliferation in response to activation of PPARD with an agonist (GW0742) or an inverse agonist (DG172) or the effect of inhibiting ERK signaling in TM4 cells[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

455.22

Formula

C₂₀H₂₂BrCl₂N₃

CAS No.

1361504-77-9

SMILES

BrC(C=CC=C1)=C1/C(C#N)=C/C(C=C2)=CC=C2N3CCN(C)CC3.[H]Cl.[H]Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
DG172 dihydrochloride
Cat. No.:
HY-19737A
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