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Cat. No.: HY-147925

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hCAI/II-IN-4

hCAI/II-IN-4 (compound 6d) is a potent dual hCA I/II inhibitor with K_i values of 16.95, 15.22 and 27.04 nM for hCA I, hCA II and hCA Ⅸ, respectively. hCAI/II-IN-4 has anti-hypoxia activities and low toxicity. hCAI/II-IN-4 can be used for acute mountain sickness (AMS) research.

For research use only. We do not sell to patients.

CAS No.: 2480284-01-1
Formula: C₁₅H₁₅N₃O₅S₂
Molecular Weight:381.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

hCAI/II-IN-4 Chemical Structure

CAS No.: 2480284-01-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

K_i:16.95 nM (hCA I)、15.22 nM (hCA II) and 27.04 nM (hCA Ⅸ)

All Carbonic Anhydrase Isoforms :

In Vitro

hCAI/II-IN-4 (compound 6d) (5-200μM; 48 hours) has no apparent cytotoxicity in HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HEK293 cells
Concentration:

5, 25, 50, 100 and 200 μM
Incubation Time:

48 hours
Result:

The cell viability rate was higher than 60%.

In Vivo

hCAI/II-IN-4 (compound 6d) (400-2000 mg/kg; p.o.; Male BLAB/c mice of hypoxia) has no apparent toxic effect in vivo^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male BLAB/c mice of hypoxia^[1]
Dosage:

400, 500 and 2000 mg/kg
Administration:

Oral administration
Result:

Prolonged the survival time of mice by 29.3% compared with that of the blank control group.

Chemical Information

CAS No. 2480284-01-1
Molecular Weight 381.43
Formula C₁₅H₁₅N₃O₅S₂
SMILES

O=C(C1=CSC(NC(C2=CC=C(S(=O)(N)=O)C=C2)=O)=N1)OCC3CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang C, et al. N-Quinary heterocycle-4-sulphamoylbenzamides exert anti-hypoxic effects as dual inhibitors of carbonic anhydrases I/II. Bioorg Chem. 2020 Jul;100:103931. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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hCAI/II-IN-4

All Carbonic Anhydrase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

hCAI/II-IN-4 Related Classifications

HY-147925 Related Classifications