2480284-01-1
2480284-01-1
Chemical Structure
CAI/II-IN-4
- CAS No.: 2480284-01-1
- Formula:C15H15N3O5S2
- Molecular Weight:381.43
IUPAC Name: N-(4-(N-(2-amino-2-oxoethyl)-N-(4-((N-(2-amino-2-oxoethyl)-4-methoxyphenyl)sulfonamido)naphthalen-1-yl)sulfamoyl)phenyl)-3-(4-ethylpiperazin-1-yl)propanamide
InChIKey: GNWGBZOLHBOSHB-UHFFFAOYSA-N
SMILES: O=C(C1=CSC(NC(C2=CC=C(S(=O)(N)=O)C=C2)=O)=N1)OCC3CC3
Biological Activity: CAI/II-IN-4 (compound 6d) is a potent dual hCA I/II inhibitor with Ki values of 16.95, 15.22 and 27.04 nM for hCA I, hCA II and hCA Ⅸ, respectively. CAI/II-IN-4 has anti-hypoxia activities and low toxicity. CAI/II-IN-4 can be used for acute mountain sickness (AMS) research[1].
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CAI/II-IN-4 | CAI/II-IN-4 (compound 6d) is a potent dual hCA I/II inhibitor with Ki values of 16.95, 15.22 and 27.04 nM for hCA I, hCA II and hCA Ⅸ, respectively. CAI/II-IN-4 has anti-hypoxia activities and low toxicity. CAI/II-IN-4 can be used for acute mountain sickness (AMS) research. | |||||||||||||||||||||
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