1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. PD-1/PD-L1-IN-14

PD-1/PD-L1-IN-14 

Cat. No.: HY-144258
Handling Instructions

PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1.

For research use only. We do not sell to patients.

PD-1/PD-L1-IN-14 Chemical Structure

PD-1/PD-L1-IN-14 Chemical Structure

CAS No. : 2499965-12-5

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Description

PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1[1].

IC50 & Target

IC50: 27.8 nM (PD-1/PD-L1)[1].

In Vitro

PD-1/PD-L1-IN-14 (compound 17) promotes cell-surface PD-L1 internalized into the cytosol and induces the degradation of PD-L1 in tumor cells through a lysosome-dependent pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

400.47

Formula

C24H24N4O2

CAS No.
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Storage

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Product Name:
PD-1/PD-L1-IN-14
Cat. No.:
HY-144258
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