1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. BMS-1166 hydrochloride

BMS-1166 hydrochloride 

Cat. No.: HY-102011A
Handling Instructions

BMS-1166 hydrochloride is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

For research use only. We do not sell to patients.

BMS-1166 hydrochloride Chemical Structure

BMS-1166 hydrochloride Chemical Structure

CAS No. : 2113650-05-6

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Description

BMS-1166 hydrochloride is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

IC50 & Target

IC50: 1.4 nM (PD-1/PD-L1 interaction)[1].

In Vitro

BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay[1]. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose dependently abolishes the inhibition of ECs stimulation by sPD-L1[2].

Molecular Weight

677.57

Formula

C₃₆H₃₄Cl₂N₂O₇

CAS No.

2113650-05-6

SMILES

O=C(O)[[email protected]@H]1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C(OCCO5)C5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)C[[email protected]](O)C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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BMS-1166 hydrochloride
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HY-102011A
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