1. Immunology/Inflammation
  2. PD-1/PD-L1

BMS-1166 (Synonyms: PD-1/PD-L1-IN1)

Cat. No.: HY-102011
Handling Instructions

BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM.

For research use only. We do not sell to patients.

BMS-1166 Chemical Structure

BMS-1166 Chemical Structure

CAS No. : 1818314-88-3

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  • Biological Activity

  • Technical Information

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Description

BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM.

IC50 & Target

IC50: 1.4 nM (PD-1/PD-L1 interaction)[1].

In Vitro

BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay[1]. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose dependently abolishes the inhibition of ECs stimulation by sPD-L1[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5598 mL 7.7990 mL 15.5979 mL
5 mM 0.3120 mL 1.5598 mL 3.1196 mL
10 mM 0.1560 mL 0.7799 mL 1.5598 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

641.11

Formula

C₃₆H₃₃ClN₂O₇

CAS No.

1818314-88-3

SMILES

O=C(O)[[email protected]@H]1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C(OCCO5)C5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)C[[email protected]](O)C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
BMS-1166
Cat. No.:
HY-102011
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BMS-1166

Cat. No.: HY-102011