1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. BMS-1166

BMS-1166 

Cat. No.: HY-102011 Purity: 99.86%
Handling Instructions

BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

For research use only. We do not sell to patients.

BMS-1166 Chemical Structure

BMS-1166 Chemical Structure

CAS No. : 1818314-88-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 776 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of BMS-1166:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

IC50 & Target

IC50: 1.4 nM (PD-1/PD-L1 interaction)[1].

In Vitro

BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay[1]. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose dependently abolishes the inhibition of ECs stimulation by sPD-L1[2].

Molecular Weight

641.11

Formula

C₃₆H₃₃ClN₂O₇

CAS No.

1818314-88-3

SMILES

O=C(O)[[email protected]@H]1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C(OCCO5)C5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)C[[email protected]](O)C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (194.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5598 mL 7.7990 mL 15.5979 mL
5 mM 0.3120 mL 1.5598 mL 3.1196 mL
10 mM 0.1560 mL 0.7799 mL 1.5598 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.86%

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Product Name:
BMS-1166
Cat. No.:
HY-102011
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