PD-1/PD-L1-IN-29
Based on 1 Customer Validation
PD-1/PD-L1-IN-29 (S4-1) is a potent PD-1/PD-L1 inhibitor with an IC50 value of 6.1 nM. PD-1/PD-L1-IN-29 binds PD-L1 and disrupts PD-1/PD-L1 interactions, induces PD-L1 dimerization and internalization, improves its localization to the endoplasmic reticulum, and promotes PD-L1 entry into the endoplasmic reticulum. PD-1/PD-L1-IN-29 has anticancer activity.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 2665734-13-2
- Formula: C26H24N2O6
- Molecular Weight:460.48
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PD-1/PD-L1-IN-29(S4-1) (10 or 20 μM, 48 h) can increase the cytotoxicity of PBMCs against A375 tumor cells by blocking PD-1/PD-L1 interaction and restoring the activation state of PBMCs, with little direct killing effect on tumor cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
The pharmacokinetic parameters of PD-1/PD-L1-IN-29(S4-1) in mice
| Parameters | iv (5 mg/kg) | po (50 mg/kg) |
| T1/2 (h) | 9.78 | 4.77 |
| Tmax (h) | 0.08 | 0.92 |
| Cmax (ng/mL) | 6290 | 260.67 |
| AUC0-t (h*ng/mL) | 3466.58/td> | 808.04 |
| AUC0-∞ (h*ng/mL) | 3566.62 | 830.34 |
| CL (mL/h/kg) | 1404.22 | - |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2665734-13-2
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Appearance Solid
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Molecular Weight 460.48
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Formula C26H24N2O6
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Color White to light yellow
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SMILES
OC[C@H](NCC1=CC2=C(C=C1OC)C(N(C2=O)C3=C(C(C4=CC=CC=C4)=CC=C3)C)=O)C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 66.67 mg/mL (144.78 mM; ultrasonic and adjust pH to 2 with 1M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1716 mL | 10.8582 mL | 21.7165 mL | 54.2912 mL |
| 5 mM | 0.4343 mL | 2.1716 mL | 4.3433 mL | 10.8582 mL | |
| 10 mM | 0.2172 mL | 1.0858 mL | 2.1716 mL | 5.4291 mL | |
| 15 mM | 0.1448 mL | 0.7239 mL | 1.4478 mL | 3.6194 mL | |
| 20 mM | 0.1086 mL | 0.5429 mL | 1.0858 mL | 2.7146 mL | |
| 25 mM | 0.0869 mL | 0.4343 mL | 0.8687 mL | 2.1716 mL | |
| 30 mM | 0.0724 mL | 0.3619 mL | 0.7239 mL | 1.8097 mL | |
| 40 mM | 0.0543 mL | 0.2715 mL | 0.5429 mL | 1.3573 mL | |
| 50 mM | 0.0434 mL | 0.2172 mL | 0.4343 mL | 1.0858 mL | |
| 60 mM | 0.0362 mL | 0.1810 mL | 0.3619 mL | 0.9049 mL | |
| 80 mM | 0.0271 mL | 0.1357 mL | 0.2715 mL | 0.6786 mL | |
| 100 mM | 0.0217 mL | 0.1086 mL | 0.2172 mL | 0.5429 mL |
PD-1/PD-L1-IN-29 Related Classifications
HY-152240 Related Classifications
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