PD-1/PD-L1-IN-23
Based on 1 Customer Validation
PD-1/PD-L1-IN-23 is a potent and orally active inhibitor of PD-1/PD-L1. PD-1/PD-L1-IN-23 is an ester proagent of L7. L7 is a benzo[c][1,2,5]oxadiazole derivative and biologically evaluated as inhibitors of PD-L1. PD-1/PD-L1-IN-23 displays significant antitumor effects in tumor models of syngeneic and PD-L1 humanized mice.
For research use only. We do not sell to patients.
- Purity: 99.98%
- CAS No.: 2597056-04-5
- Formula: C32H30BrCl2N3O6
- Molecular Weight:703.41
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
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Bioactive Compound Library
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Immunology/Inflammation Compound Library
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Anti-Cancer Compound Library
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Small Molecule Immuno-Oncology Compound Library
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Orally Active Compound Library
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Anti-Breast Cancer Compound Library
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Anti-Lung Cancer Compound Library
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Anti-Blood Cancer Compound Library
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Anti-Liver Cancer Compound Library
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Anti-Colorectal Cancer Compound Library
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Protein-protein Interaction Inhibitor Library
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Membrane Protein-targeted Compound Library
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Membrane Receptor-targeted Compound Library
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Anti-Hematopathy Compound Library
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Anti-Ovarian Cancer Compound Library
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MCE Bioactive Compound Library
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Anti-Gastric Cancer Compound Library
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Anti-Brain Cancer Compound Library
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High-Throughput Bioactive Compound Library
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Biological Activity
PD-1/PD-L1[1]
Chemical Information
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CAS No. 2597056-04-5
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Appearance Solid
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Molecular Weight 703.41
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Formula C32H30BrCl2N3O6
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Color White to off-white
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SMILES
ClC1=CC(CN[C@@H](C(OCC)=O)CO)=C(OCC2=CC3=NON=C3C=C2)C=C1OCC4=C(Br)C(C5=CC=CC=C5)=CC=C4.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (355.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (2.96 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4216 mL | 7.1082 mL | 14.2165 mL | 35.5412 mL |
| 5 mM | 0.2843 mL | 1.4216 mL | 2.8433 mL | 7.1082 mL | |
| 10 mM | 0.1422 mL | 0.7108 mL | 1.4216 mL | 3.5541 mL | |
| 15 mM | 0.0948 mL | 0.4739 mL | 0.9478 mL | 2.3694 mL | |
| 20 mM | 0.0711 mL | 0.3554 mL | 0.7108 mL | 1.7771 mL | |
| 25 mM | 0.0569 mL | 0.2843 mL | 0.5687 mL | 1.4216 mL | |
| 30 mM | 0.0474 mL | 0.2369 mL | 0.4739 mL | 1.1847 mL | |
| 40 mM | 0.0355 mL | 0.1777 mL | 0.3554 mL | 0.8885 mL | |
| 50 mM | 0.0284 mL | 0.1422 mL | 0.2843 mL | 0.7108 mL | |
| 60 mM | 0.0237 mL | 0.1185 mL | 0.2369 mL | 0.5924 mL | |
| 80 mM | 0.0178 mL | 0.0889 mL | 0.1777 mL | 0.4443 mL | |
| 100 mM | 0.0142 mL | 0.0711 mL | 0.1422 mL | 0.3554 mL |
PD-1/PD-L1-IN-23 Related Classifications
HY-145774 Related Classifications
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