1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. PD-1/PD-L1-IN-23

PD-1/PD-L1-IN-23 

Cat. No.: HY-145774 Purity: 99.88%
Handling Instructions

PD-1/PD-L1-IN-23 is a potent and orally active inhibitor of PD-1/PD-L1. PD-1/PD-L1-IN-23 is an ester prodrug of L7. L7 is a benzo[c][1,2,5]oxadiazole derivative and biologically evaluated as inhibitors of PD-L1. PD-1/PD-L1-IN-23 displays significant antitumor effects in tumor models of syngeneic and PD-L1 humanized mice.

For research use only. We do not sell to patients.

PD-1/PD-L1-IN-23 Chemical Structure

PD-1/PD-L1-IN-23 Chemical Structure

CAS No. : 2597056-04-5

Size Price Stock Quantity
5 mg USD 740 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1170 In-stock
Estimated Time of Arrival: December 31
25 mg USD 2350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 5650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

PD-1/PD-L1-IN-23 is a potent and orally active inhibitor of PD-1/PD-L1. PD-1/PD-L1-IN-23 is an ester prodrug of L7. L7 is a benzo[c][1,2,5]oxadiazole derivative and biologically evaluated as inhibitors of PD-L1. PD-1/PD-L1-IN-23 displays significant antitumor effects in tumor models of syngeneic and PD-L1 humanized mice[1].

IC50 & Target

PD-1/PD-L1[1]

Molecular Weight

703.41

Formula

C32H30BrCl2N3O6

CAS No.
SMILES

ClC1=CC(CN[[email protected]@H](C(OCC)=O)CO)=C(OCC2=CC3=NON=C3C=C2)C=C1OCC4=C(Br)C(C5=CC=CC=C5)=CC=C4.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (355.41 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4216 mL 7.1082 mL 14.2165 mL
5 mM 0.2843 mL 1.4216 mL 2.8433 mL
10 mM 0.1422 mL 0.7108 mL 1.4216 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (2.96 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.96 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Product Name:
PD-1/PD-L1-IN-23
Cat. No.:
HY-145774
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