1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. PD-1-IN-24

PD-1-IN-24 

Cat. No.: HY-134886
Handling Instructions

PD-1-IN-24 (compound 1) is an orally active PD-1 inhibitor.

For research use only. We do not sell to patients.

PD-1-IN-24 Chemical Structure

PD-1-IN-24 Chemical Structure

CAS No. : 2360909-50-6

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Description

PD-1-IN-24 (compound 1) is an orally active PD-1 inhibitor[1].

In Vivo

PD-1-IN-24 (compound 1, 15mg/kg, PO, BID) exhibits TGI(%) of 19.96% in the subcutaneous 4T1 murine breast cancer model in BALB/c mice[1].
PD-1-IN-24 (compound 1, 15mg/kg, PO, BID) dose-dependently inhibits tumor growth in the Bl6F10 models with TGI% of 35.59% (30 mg/kg), 38.87% (60 mg/kg) and 47.35% (120 mg/kg), respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

469.50

Formula

C₂₇H₂₆F₃NO₃

CAS No.
SMILES

CC1=C(C2=CC=CC=C2)C=CC=C1/C=C/C3=C(C=CC(CN[[email protected]](CO)(C)C(O)=O)=C3)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PD-1-IN-24PD-1/PD-L1PD-1/Programmed death-ligand 1breastcancerBl6F10TGIInhibitorinhibitorinhibit

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PD-1-IN-24
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