1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. PD-1-IN-24

PD-1-IN-24 

Cat. No.: HY-134886 Purity: 98.04% ee.: 100.00%
COA Handling Instructions

PD-1-IN-24 (compound 1) is an orally active PD-1 inhibitor.

For research use only. We do not sell to patients.

PD-1-IN-24 Chemical Structure

PD-1-IN-24 Chemical Structure

CAS No. : 2360909-50-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 465 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 465 In-stock
Solid
5 mg USD 450 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
50 mg USD 2550 In-stock
100 mg USD 3900 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PD-1-IN-24 (compound 1) is an orally active PD-1 inhibitor[1].

In Vivo

PD-1-IN-24 (compound 1, 15mg/kg, PO, BID) exhibits TGI(%) of 19.96% in the subcutaneous 4T1 murine breast cancer model in BALB/c mice[1].
PD-1-IN-24 (compound 1, 15mg/kg, PO, BID) dose-dependently inhibits tumor growth in the Bl6F10 models with TGI% of 35.59% (30 mg/kg), 38.87% (60 mg/kg) and 47.35% (120 mg/kg), respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

469.50

Appearance

Solid

Formula

C27H26F3NO3

CAS No.
SMILES

CC1=C(C2=CC=CC=C2)C=CC=C1/C=C/C3=C(C=CC(CN[[email protected]](CO)(C)C(O)=O)=C3)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (212.99 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1299 mL 10.6496 mL 21.2993 mL
5 mM 0.4260 mL 2.1299 mL 4.2599 mL
10 mM 0.2130 mL 1.0650 mL 2.1299 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 5 mg/mL (10.65 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (10.65 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (10.65 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
PD-1-IN-24
Cat. No.:
HY-134886
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