COQ7-IN-2
Based on 1 publication(s) in Google Scholar
COQ7-IN-2 (compound 12) is an inhibitor of COQ7, witn IC50 values of 7.3 μM and 15.4 μM for DMQ10 and UQ10 accumulation, respectively.
For research use only. We do not sell to patients.
- Purity: 99.74%
- CAS No.: 2579696-76-5
- Formula: C15H13N3O
- Molecular Weight:251.28
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) COQ7-IN-2
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C3A | GI50 |
18.5 μM
Compound: 12
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Growth inhibition of human C3A cells assessed as growth inhibition after 3 days by cell-titer-Glo assay
Growth inhibition of human C3A cells assessed as growth inhibition after 3 days by cell-titer-Glo assay
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[PMID: 31753803] |
| C3A | GI50 |
20.2 μM
Compound: 12
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Growth inhibition of human C3A cells after 3 days in presence of 10 mM 2-DG by cell-titer-Glo assay
Growth inhibition of human C3A cells after 3 days in presence of 10 mM 2-DG by cell-titer-Glo assay
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[PMID: 31753803] |
| HeLa | GI50 |
>12 μM
Compound: 12
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Growth inhibition of human HeLa cells assessed as growth inhibition after 3 days by cell-titer-Glo assay
Growth inhibition of human HeLa cells assessed as growth inhibition after 3 days by cell-titer-Glo assay
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[PMID: 31753803] |
| PANC-1 | GI50 |
>12 μM
Compound: 12
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Growth inhibition of human PANC1 cells after 3 days by cell-titer-Glo assay
Growth inhibition of human PANC1 cells after 3 days by cell-titer-Glo assay
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[PMID: 31753803] |
| PC-3 | GI50 |
>12 μM
Compound: 12
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Cytotoxicity against human PC3 cells assessed as growth inhibition after 3 days by cell-titer-Glo assay
Cytotoxicity against human PC3 cells assessed as growth inhibition after 3 days by cell-titer-Glo assay
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[PMID: 31753803] |
COQ7-IN-2 (compound 12) has less growth inhibition against human normal culture cells[1].
The substantial DMQ10 accumulation occurred in both PANC-1 cells (8.7% by COQ7-IN-2 (compound 12)) and PC3 cells (14.0% by COQ7-IN-2 (compound 12))[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2579696-76-5
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Appearance Solid
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Molecular Weight 251.28
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Formula C15H13N3O
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Color White to off-white
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SMILES
OC1=CC(C2=CC=CC=C2)=NN1C3=NC=C(C)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Chem Biol Interact
4-Hydroxybenzoic acid restrains Nlrp3 inflammasome priming and activation via disrupting PU.1 DNA binding activity and direct antioxidation. [Abstract]2024 Dec 1:404:111262. PMID: 39389441
Solvent & Solubility
DMSO : 25 mg/mL (99.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9796 mL | 19.8981 mL | 39.7962 mL | 99.4906 mL |
| 5 mM | 0.7959 mL | 3.9796 mL | 7.9592 mL | 19.8981 mL | |
| 10 mM | 0.3980 mL | 1.9898 mL | 3.9796 mL | 9.9491 mL | |
| 15 mM | 0.2653 mL | 1.3265 mL | 2.6531 mL | 6.6327 mL | |
| 20 mM | 0.1990 mL | 0.9949 mL | 1.9898 mL | 4.9745 mL | |
| 25 mM | 0.1592 mL | 0.7959 mL | 1.5918 mL | 3.9796 mL | |
| 30 mM | 0.1327 mL | 0.6633 mL | 1.3265 mL | 3.3164 mL | |
| 40 mM | 0.0995 mL | 0.4975 mL | 0.9949 mL | 2.4873 mL | |
| 50 mM | 0.0796 mL | 0.3980 mL | 0.7959 mL | 1.9898 mL | |
| 60 mM | 0.0663 mL | 0.3316 mL | 0.6633 mL | 1.6582 mL | |
| 80 mM | 0.0497 mL | 0.2487 mL | 0.4975 mL | 1.2436 mL |
COQ7-IN-2 Related Classifications
HY-138429 Related Classifications
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