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Cat. No.: HY-150593

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IRAK4-IN-16

IRAK4-IN-16 (compound 4) is a potent IRAK4 (interleukin-1 receptor associated kinase 4) inhibitor, with an IC₅₀ of 2.5 nM. IRAK4-IN-16 shows cytotoxicity activity against OCI-LY10, TMD8, Ramos and HT cells, with IC₅₀ values of 0.2, 0.2, 0.6, and 2.7 μM, respectively.

For research use only. We do not sell to patients.

CAS No.: 1812188-83-2
Formula: C₁₇H₂₀F₂N₈O
Molecular Weight:390.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

IRAK4-IN-16 Chemical Structure

CAS No.: 1812188-83-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IRAK4

2.5 ± 0.8 nM (IC₅₀)

All IRAK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HT	IC₅₀	2.7 μM Compound: 4	Cytotoxicity against human HT cells harboring MYD88 assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against human HT cells harboring MYD88 assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 32014679]
OCI-Ly10	IC₅₀	0.2 μM Compound: 4	Cytotoxicity against human OCILY10 cells harboring MYD88 L265P mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against human OCILY10 cells harboring MYD88 L265P mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 32014679]
Ramos	IC₅₀	0.6 μM Compound: 4	Cytotoxicity against human Ramos cells harboring MYD88 assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against human Ramos cells harboring MYD88 assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 32014679]
TMD8	IC₅₀	0.2 μM Compound: 4	Cytotoxicity against human TMD8 cells harboring MYD88 L265P mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against human TMD8 cells harboring MYD88 L265P mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 32014679]

Chemical Information

CAS No. 1812188-83-2
Molecular Weight 390.39
Formula C₁₇H₂₀F₂N₈O
SMILES

FC(F)C1=NN(C=C1NC(C2=C3N(C=CC(N[C@@H]4CCCNC4)=N3)N=C2)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen Y, et al. Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma. Eur J Med Chem. 2020 Mar 15;190:112092. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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IRAK4-IN-16

All IRAK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

IRAK4-IN-16 Related Classifications

HY-150593 Related Classifications