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製品番号: HY-150593

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IRAK4-IN-16

IRAK4-IN-16 (compound 4) is a potent IRAK4 (interleukin-1 receptor associated kinase 4) inhibitor, with an IC₅₀ of 2.5 nM. IRAK4-IN-16 shows cytotoxicity activity against OCI-LY10, TMD8, Ramos and HT cells, with IC₅₀ values of 0.2, 0.2, 0.6, and 2.7 μM, respectively.

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CAS 番号: 1812188-83-2
分子式: C₁₇H₂₀F₂N₈O
分子量:390.39

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

IRAK4-IN-16 構造式

CAS 番号: 1812188-83-2

容量

価格（税別）

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

IRAK4

2.5 ± 0.8 nM (IC₅₀)

IRAK アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HT	IC₅₀	2.7 μM Compound: 4	Cytotoxicity against human HT cells harboring MYD88 assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against human HT cells harboring MYD88 assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 32014679]
OCI-Ly10	IC₅₀	0.2 μM Compound: 4	Cytotoxicity against human OCILY10 cells harboring MYD88 L265P mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against human OCILY10 cells harboring MYD88 L265P mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 32014679]
Ramos	IC₅₀	0.6 μM Compound: 4	Cytotoxicity against human Ramos cells harboring MYD88 assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against human Ramos cells harboring MYD88 assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 32014679]
TMD8	IC₅₀	0.2 μM Compound: 4	Cytotoxicity against human TMD8 cells harboring MYD88 L265P mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay Cytotoxicity against human TMD8 cells harboring MYD88 L265P mutant assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay	[PMID: 32014679]

化学情報

CAS 番号 1812188-83-2
分子量 390.39
分子式 C₁₇H₂₀F₂N₈O
SMILES

FC(F)C1=NN(C=C1NC(C2=C3N(C=CC(N[C@@H]4CCCNC4)=N3)N=C2)=O)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Chen Y, et al. Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma. Eur J Med Chem. 2020 Mar 15;190:112092. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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IRAK4-IN-16

IRAK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

IRAK4-IN-16 関連分類

HY-150593 関連分類