1812188-83-2
1812188-83-2
Chemical Structure
IRAK4-IN-16
- CAS No.: 1812188-83-2
- Formula:C17H20F2N8O
- Molecular Weight:390.39
IUPAC Name: (R)-N-(3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-ylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide
InChIKey: YNYXDDGCGKZVTQ-SNVBAGLBSA-N
SMILES: FC(F)C1=NN(C=C1NC(C2=C3N(C=CC(N[C@@H]4CCCNC4)=N3)N=C2)=O)C
Biological Activity: IRAK4-IN-16 (compound 4) is a potent IRAK4 (interleukin-1 receptor associated kinase 4) inhibitor, with an IC50 of 2.5 nM. IRAK4-IN-16 shows cytotoxicity activity against OCI-LY10, TMD8, Ramos and HT cells, with IC50 values of 0.2, 0.2, 0.6, and 2.7 μM, respectively[1].
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IRAK4-IN-16 | IRAK4-IN-16 (compound 4) is a potent IRAK4 (interleukin-1 receptor associated kinase 4) inhibitor, with an IC50 of 2.5 nM. IRAK4-IN-16 shows cytotoxicity activity against OCI-LY10, TMD8, Ramos and HT cells, with IC50 values of 0.2, 0.2, 0.6, and 2.7 μM, respectively. | |||||||||||||||||||||
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