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Cat. No.: HY-139861

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CBP/p300-IN-14

CBP/p300-IN-14 is a potent inhibitor of CBP/EP300 (lysine acetyltransferase) with an IC₅₀ of 3.3 nM (extracted from patent WO2021213521A1, compound 27).

For research use only. We do not sell to patients.

CAS No.: 2725036-10-0
Formula: C₃₀H₃₁F₂N₇O₂
Molecular Weight:559.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

CBP/p300-IN-14 Chemical Structure

CAS No.: 2725036-10-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CBP/p300-IN-14 is a potent inhibitor of CBP/EP300 (lysine acetyltransferase) with an IC₅₀ of 3.3 nM (extracted from patent WO2021213521A1, compound 27)^[1].

IC₅₀ & Target

CBP/p300

All Epigenetic Reader Domain Isoforms :

All Histone Acetyltransferase Isoforms :

Chemical Information

CAS No. 2725036-10-0
Molecular Weight 559.61
Formula C₃₀H₃₁F₂N₇O₂
SMILES

O=C(C1=CC2=C(C=CC(N3C(CN(CC3)C)=O)=C2)C(N4C5=C(CCC4)C=C(C6=CN(C)N=C6)C(C(F)F)=C5)=N1)NC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang, Lisha, et al. Cbp/ep300 inhibitor and use thereof. Patent WO2021213521A1.

Calculators

Molarity Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols
Purity & Documentation
References

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CBP/p300-IN-14

All Epigenetic Reader Domain Isoforms

All Histone Acetyltransferase Isoforms

Biological Activity

Description

IC50 & Target

Chemical Information

Protocols

Purity & Documentation

References

Calculators

Help & FAQs

CBP/p300-IN-14 Related Classifications

HY-139861 Related Classifications

Bioz

Keywords

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