1. Anti-infection
  2. SARS-CoV
  3. HeE1-2Tyr

HeE1-2Tyr 

Cat. No.: HY-100749
Handling Instructions

HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 µM) activity in vitro.

For research use only. We do not sell to patients.

HeE1-2Tyr Chemical Structure

HeE1-2Tyr Chemical Structure

CAS No. : 2245195-67-7

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Description

HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 µM) activity in vitro[1][2].

IC50 & Target

Flavivirus RNA dependent RNA polymerases (RdRp)[1]
SARS-CoV-2 RdRps>[2]

In Vitro

HeE1-2Tyr shows antiviral activity, it is able to inhibit an Ugandan strain of West Nile virus with an IC50 of 2.1 µM, as well as all the four Dengue virus (DENV) serotypes, with IC50 ranging from 6.8 to 15 µM. The cytotoxicity of HeE1-2Tyr versus Vero E6 cells is ~115 µM[1].
Additionally, upon infection of human HEK 293 cells (CC50 of 50 µM), HeE1-2Tyr inhibits clinical strains of yellow fever virus with IC50 values ranging from 3.9 to 12 µM[1].
HeE1-2Tyr completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

582.67

Formula

C₃₃H₃₀N₂O₆S

CAS No.
Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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HeE1-2Tyr
Cat. No.:
HY-100749
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