2245195-67-7
2245195-67-7
Chemical Structure
HeE1-2Tyr
- CAS. Nr.: 2245195-67-7
- Formula:C33H30N2O6S
- Molecular Weight:582.67
IUPAC Name: (8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-benzo[4,5]thiazolo[3,2-a]pyridine-4-carbonyl)-L-tyrosine
InChIKey: PTUWWNGMUPSKDC-MHZLTWQESA-N
SMILES: OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC(C(C=C2C3=CC=CC=C3)=C4SC5=CC=C(OC6CCCCC6)C=C5N4C2=O)=O
Biological Activity: HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 μM) activity in vitro[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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HeE1-2Tyr | 96.68% | HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 μM) activity in vitro. | ||||||||||||||||||||
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HeE1-2Tyr (Standard) | ≥98% | HeE1-2Tyr (Standard) is the analytical standard of HeE1-2Tyr (HY-100749). This product is intended for research and analytical applications. HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. HeE1-2Tyr significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 μM) activity in vitro. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.91
HY-139442RdRP-IN-2 -
Similarity Score 0.49
HY-171854SB-583355 -
Similarity Score 0.46
HY-153339E235 -
Similarity Score 0.46
HY-103460IRL 2500 -
Similarity Score 0.46
HY-105215FK888 -
Similarity Score 0.45
HY-U00207MEN11467 -
Similarity Score 0.45
HY-U00320Neurokinin antagonist 1 -
Similarity Score 0.45
HY-P5275Tripeptide-41 -
Similarity Score 0.45
HY-129658TT-OAD2 free base -
Explore the MedChemAI to find more analogs
References
- [1]. Delia Tarantino, et al. Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor. Antiviral Res. 2016 Oct;134:226-235. [Content Brief]
- [2]. Milan Dejmek, et al. Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication. Viruses. 2021 Aug 11;13(8):1585. [Content Brief]
