RdRP-IN-2
Based on 1 Customer Validation
RdRP-IN-2 is a RNA dependent RNA polymerase (RdRp) inhibitor. RdRP-IN-2 significantly inhibits SARS-CoV-2 RdRp with an IC50 of 41.2 μM.RdRP-IN-2 also inhibits Feline coronavirus (FIPV) replication.
For research use only. We do not sell to patients.
- Purity: 98.01%
- CAS No.: 2863657-16-1
- Formula: C33H30N2O5S
- Molecular Weight:566.67
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All DNA/RNA Synthesis Isoforms
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Biological Activity
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RNA Polymerase |
RdRP-IN-2 (Compound 17) completely inhibits the replication of both SARS-CoV-2 and Feline coronavirus (FIPV). RdRP-IN-2 is not cytotoxic for Vero and CRFK cells[1].
RdRP-IN-2 (Compound 17) shows anti-SARS-CoV-2 activities with an EC50 value of 527.3 nM in Vero cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2863657-16-1
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Appearance Solid
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Molecular Weight 566.67
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Formula C33H30N2O5S
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Color Light yellow to green yellow
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SMILES
O=C(O)[C@H](CC1=CC=CC=C1)NC(C(C=C2C3=CC=CC=C3)=C(SC4=CC=C(OC5CCCCC5)C=C46)N6C2=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (176.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7647 mL | 8.8235 mL | 17.6470 mL | 44.1174 mL |
| 5 mM | 0.3529 mL | 1.7647 mL | 3.5294 mL | 8.8235 mL | |
| 10 mM | 0.1765 mL | 0.8823 mL | 1.7647 mL | 4.4117 mL | |
| 15 mM | 0.1176 mL | 0.5882 mL | 1.1765 mL | 2.9412 mL | |
| 20 mM | 0.0882 mL | 0.4412 mL | 0.8823 mL | 2.2059 mL | |
| 25 mM | 0.0706 mL | 0.3529 mL | 0.7059 mL | 1.7647 mL | |
| 30 mM | 0.0588 mL | 0.2941 mL | 0.5882 mL | 1.4706 mL | |
| 40 mM | 0.0441 mL | 0.2206 mL | 0.4412 mL | 1.1029 mL | |
| 50 mM | 0.0353 mL | 0.1765 mL | 0.3529 mL | 0.8823 mL | |
| 60 mM | 0.0294 mL | 0.1471 mL | 0.2941 mL | 0.7353 mL | |
| 80 mM | 0.0221 mL | 0.1103 mL | 0.2206 mL | 0.5515 mL | |
| 100 mM | 0.0176 mL | 0.0882 mL | 0.1765 mL | 0.4412 mL |
RdRP-IN-2 Related Classifications
HY-139442 Related Classifications
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