MK2-IN-5
Based on 1 publication(s) in Google Scholar
MK2-IN-5 is a Mk2 pseudosubstrate (Ki= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation.
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- CAS. Nr.: 474713-20-7
- Formel: C61H113N21O16
- Molecular Weight:1396.68
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) MK2-IN-5
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Biologische Aktivität
Beschreibung
IC50 & Target
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ERK1 |
ERK2 |
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ventilator-associated lung injury model[2]
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Dosage:2 mg/kg
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Administration:Intraperitoneal injection (i.p.)
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Result:Decreased HSP25 phosphorylation.
Chemical Information
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CAS. Nr. 474713-20-7
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Molecular Weight 1396.68
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Formel C61H113N21O16
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Synonyms
Hsp25 kinase inhibitor; Mk2 pseudosubstrate
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Sequence
Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala
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Sequence Shortening
KKKALNRQLGVAA
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Enhancing CAR-T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF-Mediated Angiogenesis. [Abstract]2026 May 6:e21975. PMID: 42089445
Reinheit & Dokumentation
Verweise
[1]. Gaestel M, et al. Peptides as signaling inhibitors for mammalian MAP kinase cascades [J]. Current pharmaceutical design, 2009, 15(21): 2471-2480. [Content Brief]
[2]. Damarla M, et al. Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury [J]. PloS one, 2009, 4(2): e4600. [Content Brief]
[3]. Lopes L B, et al. Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor [J]. Biochemical and biophysical research communications, 2009, 382(3): 535-539. [Content Brief]
Hot Topics
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Topics Protein-Protein Interaction: Therapeutic Target-Beyond Cancer
Protein-protein interactions (PPIs) constitute the molecular framework that organizes signaling networks, gene regulation, metabolism, immunity, and cellular homeostasis.
2026-06-18
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Topics A Review of the Mechanisms and Applications of Protein-Protein Interactions (PPIs)
Protein-protein interactions (PPIs) are physical or functional connections formed by two or more proteins through specific interfaces, and they underlie signal transduction, transcriptional regulation, protein degradation, cell-cycle control, DNA repair, immune recognition, and cell death.
2026-06-18
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MK2-IN-5 Related Classifications
HY-P10072 Related Classifications
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Keywords
- MK2-IN-5
- 474713-20-7
- Hsp25 kinase inhibitor
- Mk2 pseudosubstrate
- ERK
- JNK
- p38 MAPK
- HSP
- MAPKAPK2 (MK2)
- Extracellular signal regulated kinases
- c-Jun N-terminal kinase
- Heat shock proteins
- Mitogen-activated protein kinase activated protein kinase 2
- MAP kinase activated protein kinase 2
- MAPK activated protein kinase 2
- MAPKAP kinase 2
- MAPK
- Peptide
- Inhibitor
- inhibitor
- inhibit