MK2-IN-5
MK2-IN-5 is a Mk2 pseudosubstrate (Ki= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation.
For research use only. We do not sell to patients.
- CAS No.: 474713-20-7
- Formula: C61H113N21O16
- Molecular Weight:1396.68
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
ERK1 |
ERK2 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:ventilator-associated lung injury model[2]
-
Dosage:2 mg/kg
-
Administration:Intraperitoneal injection (i.p.)
-
Result:Decreased HSP25 phosphorylation.
Chemical Information
-
CAS No. 474713-20-7
-
Molecular Weight 1396.68
-
Formula C61H113N21O16
-
Synonyms
Hsp25 kinase inhibitor; Mk2 pseudosubstrate
-
Sequence
Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala
-
Sequence Shortening
KKKALNRQLGVAA
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Gaestel M, et al. Peptides as signaling inhibitors for mammalian MAP kinase cascades [J]. Current pharmaceutical design, 2009, 15(21): 2471-2480. [Content Brief]
[2]. Damarla M, et al. Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury [J]. PloS one, 2009, 4(2): e4600. [Content Brief]
[3]. Lopes L B, et al. Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor [J]. Biochemical and biophysical research communications, 2009, 382(3): 535-539. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz