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BY27 

Cat. No.: HY-126325
Handling Instructions

BY27 is a potent and selective BET BD2 inhibitor, shows 38, 5, 7, and 21-fold BD1/BD2 selectivity for BRD2, BRD3, BRD4, and BRDT. Anti-cancer activity.

For research use only. We do not sell to patients.

BY27 Chemical Structure

BY27 Chemical Structure

CAS No. : 2247236-59-3

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Description

BY27 is a potent and selective BET BD2 inhibitor, shows 38, 5, 7, and 21-fold BD1/BD2 selectivity for BRD2, BRD3, BRD4, and BRDT. Anti-cancer activity[1].

IC50 & Target[1]

BRD2 BD2

3.1 nM (Ki)

BRD2 BD1

95.5 nM (Ki)

BRD3 BD2

5.3 nM (Ki)

BRD3 BD1

77.9 nM (Ki)

BRD4 BD2

7.3 nM (Ki)

BRD4 BD1

80 nM (Ki)

BRD2 BD2

1.2 nM (Kd)

BRD2 BD1

45 nM (Kd)

BRD3 BD2

2.6 nM (Kd)

BRD3 BD1

12 nM (Kd)

BRD4 BD2

3.5 nM (Kd)

BRD4 BD1

26 nM (Kd)

BRDT BD2

3 nM (Kd)

BRDT BD1

64 nM (Kd)

Molecular Weight

404.90

Formula

C₂₂H₂₁ClN₆

CAS No.

2247236-59-3

SMILES

CN1N=CC(C2=CC=C(N3C(CC[[email protected]]4NC5=CC=C(Cl)C=C5)=NN=C3C)C4=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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