1. Anti-infection
  2. HIV
  3. GSK3532795

GSK3532795 (Synonyms: BMS-955176)

Cat. No.: HY-112714
Handling Instructions

GSK3532795 (BMS-955176) is a potent, orally active, second-generation HIV-1 maturation inhibitor, with EC50s of 1.9, 10.2, 2.7 and 13 nM for HIV-1 WT, HIV-1 WT(human serum), HIV-1 V370A, and HIV-1 ΔV370, respectively.

For research use only. We do not sell to patients.

GSK3532795 Chemical Structure

GSK3532795 Chemical Structure

CAS No. : 1392312-45-6

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Description

GSK3532795 (BMS-955176) is a potent, orally active, second-generation HIV-1 maturation inhibitor, with EC50s of 1.9, 10.2, 2.7 and 13 nM for HIV-1 WT, HIV-1 WT(human serum), HIV-1 V370A, and HIV-1 ΔV370, respectively[1].

IC50 & Target

EC50: 1.9 nM (HIV-1 WT), 10.2 nM (HIV-1 WT(human serum)), 2.7 nM (HIV-1 V370A), 13 nM (HIV-1 ΔV370)[1]

In Vitro

GSK3532795 exhibits Kds of 3.2 ± 0.6, 4.3 ± 2.0, 6.5 ± 2.2 and 33.6 ± 5.9 nM for HIV WT, HIV V362I, HIV V370A, HIV ΔV370, respectively[1].

Clinical Trial
Molecular Weight

691.02

Formula

C₄₂H₆₂N₂O₄S

CAS No.

1392312-45-6

SMILES

CC1(C)C(C2=CC=C(C(O)=O)C=C2)=CC[[email protected]@]3(C)[[email protected]@]1([H])CC[[email protected]]4(C)[[email protected]]3([H])CC[[email protected]@]5([H])[[email protected]@]4(C)CC[[email protected]]6(NCCN7CCS(CC7)(=O)=O)[[email protected]]5([H])[[email protected]](C(C)=C)CC6

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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