1. JAK/STAT Signaling
  2. Pim
  3. R8-T198wt

R8-T198wt 

Cat. No.: HY-P1404
Handling Instructions

R8-T198wt is a cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. R8-T198wt inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. R8-T198wt also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. R8-T198wt displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.

For research use only. We do not sell to patients.

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R8-T198wt Chemical Structure

R8-T198wt Chemical Structure

CAS No. : 2305815-72-7

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Description

R8-T198wt is a cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. R8-T198wt inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. R8-T198wt also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. R8-T198wt displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.

Molecular Weight

2820.33

Formula

C₁₁₁H₂₁₁N₅₉O₂₆S

CAS No.

2305815-72-7

Sequence

Gly-Gly-Gly-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Cys-Lys-Lys-Pro-Gly-Leu-Arg-Arg-Arg-Gln-Thr

Sequence Shortening

GGGRRRRRRRRGCKKPGLRRRQT

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

R8-T198wtPimPim kinasesInhibitorinhibitorinhibit

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R8-T198wt
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HY-P1404
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