BTK-IN-7
BTK-IN-7 is a potent and selective inhibitor of BTK (IC50=4.0 nM). BTK-IN-7 has high selectivity in both enzymatic (ITK >250-fold, EGFR >2500-fold) and cellular levels (ITK >227-fold, EGFR 27-fold). BTK-IN-7 also has potent antitumor activity.
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- CAS No.: 2952702-39-3
- 화학식: C30H32N6O4
- 분자량:540.61
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U-937 | IC50 |
3.6 μM
Compound: 24a
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Antiproliferative activity against human U-937 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human U-937 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
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[PMID: 35099969] |
BTK-IN-7 (compound 24a; 10, 100, 1000, 10000 nM; 48 hours) displays the antiproliferative effects in U-937 cells (IC50=3.6 μM)[1]. BTK-IN-7 (10, 100, 1000, 10000 nM; 48 hours; U937 cells) induces cell cycle arrest at the G1 phase in a concentration-dependent manner[1]. BTK-IN-7 (1-5 μM; 48 hours) induces apoptosis in U-937 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U937, Ramos, Pfeiffer, Jeko-1 cells
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Concentration:10, 100, 1000, 10000 nM
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Incubation Time:48 hours
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Result:Displayed antiproliferative effects in U-937 (IC50=3.6 μM) cells.
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Cell Line:U937 cells
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Concentration:10, 100, 1000, 10000 nM
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Incubation Time:48 hours
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Result:Cells were arrested atthe G1 phase in a concentration-dependent manner.
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Cell Line:U937 cells
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Concentration:1, 2.5, 5 μM
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Incubation Time:48 hours
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Result:An apoptosis rate was increased to 22.75% at a concentration of 5 μM.
BTK-IN-7 does not shows significant parenchymal injury or inflammatory cell infiltration in organs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male BALB/c nude mice (U397 xenograft mouse model) [1]
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Dosage:25, 50 mg/kg
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Administration:Intraperitoneal injection; daily for 14 days
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Result:Inhibited tumor growth in a dose-dependent manner and did not reveal significant parenchymal injury or inflammatory cell infiltration in organs.
Chemical Information
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CAS No. 2952702-39-3
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분자량 540.61
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화학식 C30H32N6O4
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SMILES
O=C1N(C2=NC(NC3=CC(OCCOC)=CC=C3)=NC=C2N=C1C4CCCCC4)C5=CC=CC(NC(C=C)=O)=C5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BTK-IN-7 Related Classifications
HY-143900 Related Classifications
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