2952702-39-3
2952702-39-3
Chemical Structure
BTK-IN-7
- CAS No.: 2952702-39-3
- Formula:C30H32N6O4
- Molecular Weight:540.61
IUPAC Name: N-(3-(6-cyclohexyl-2-((3-(2-methoxyethoxy)phenyl)amino)-7-oxopteridin-8(7H)-yl)phenyl)acrylamide
InChIKey: SRHREEZCKYAMCG-UHFFFAOYSA-N
SMILES: O=C1N(C2=NC(NC3=CC(OCCOC)=CC=C3)=NC=C2N=C1C4CCCCC4)C5=CC=CC(NC(C=C)=O)=C5
Biological Activity: BTK-IN-7 is a potent and selective inhibitor of BTK (IC50=4.0 nM). BTK-IN-7 has high selectivity in both enzymatic (ITK >250-fold, EGFR >2500-fold) and cellular levels (ITK >227-fold, EGFR 27-fold). BTK-IN-7 also has potent antitumor activity[1].
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BTK-IN-7 | BTK-IN-7 is a potent and selective inhibitor of BTK (IC50=4.0 nM). BTK-IN-7 has high selectivity in both enzymatic (ITK >250-fold, EGFR >2500-fold) and cellular levels (ITK >227-fold, EGFR 27-fold). BTK-IN-7 also has potent antitumor activity. | |||||||||||||||||||||
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References
Keywords
