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Cat. No.: HY-136299A

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Sepimostat dimethanesulfonate

(Synonyms: FUT-187)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Sepimostat dimethanesulfonate (FUT-187) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a K_i value of 27.7 µM.

For research use only. We do not sell to patients.

CAS No.: 103926-82-5
Formula: C₂₃H₂₇N₅O₈S₂
Molecular Weight:565.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Sepimostat dimethanesulfonate Chemical Structure

CAS No.: 103926-82-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
References
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Bioz

Biological Activity

Description

All iGluR Isoforms :

In Vivo

Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague Dawley rats weighing 150-300 g^[1].
Dosage:

Intravitreal injection.
Administration:

1 to 100 nmol/eye.
Result:

Exhibited neuroprotective effects significantly.

Chemical Information

CAS No. 103926-82-5
Molecular Weight 565.62
Formula C₂₃H₂₇N₅O₈S₂
SMILES

O=C(OC1=CC=C2C=C(C(N)=N)C=CC2=C1)C3=CC=C(NC4=NCCN4)C=C3.CS(=O)(O)=O.CS(=O)(O)=O
Synonyms

FUT-187
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

Eur J Pharmacol

Mechanisms of acid-sensing ion channels inhibition by nafamostat, sepimostat and diminazene. [Abstract]

2023 Jan 5:938:175394. PMID: 36403685
Res Sq

2025 Apr 07.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Masahiro Fuwa, et al. Nafamostat and Sepimostat Identified as Novel Neuroprotective Agents via NR2B N-methyl-D-aspartate Receptor Antagonism Using a Rat Retinal Excitotoxicity Model. Sci Rep. 2019 Dec 31;9(1):20409. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Sepimostat dimethanesulfonate

2 Cited Publications

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Biological Activity
- Description
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
References

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Sepimostat dimethanesulfonate

Publications Citing Use of MedChemExpress (MCE) Sepimostat dimethanesulfonate

All iGluR Isoforms

Biological Activity

Chemical Information

Publications (2)

Purity & Documentation

References

Calculators

Help & FAQs

Sepimostat dimethanesulfonate Related Classifications

HY-136299A Related Classifications