1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. Sepimostat

Sepimostat (Synonyms: FUT-187 free base)

Cat. No.: HY-136299
Handling Instructions

Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat inhibits the Ifenprodil binding with a Ki value of 27.7 µM.

For research use only. We do not sell to patients.

Sepimostat Chemical Structure

Sepimostat Chemical Structure

CAS No. : 103926-64-3

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Description

Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat inhibits the Ifenprodil binding with a Ki value of 27.7 µM[1].

In Vivo

Sepimostat (1 to 100 nmol/eye, intravitreal injection) exhibits significant neuroprotective effect[1].

Animal Model: Male Sprague Dawley rats weighing 150-300 g[1].
Dosage: Intravitreal injection.
Administration: 1 to 100 nmol/eye.
Result: Exhibited neuroprotective effects significantly.
Molecular Weight

373.41

Formula

C₂₁H₁₉N₅O₂

CAS No.

103926-64-3

SMILES

O=C(OC1=CC=C2C=C(C(N)=N)C=CC2=C1)C3=CC=C(NC4=NCCN4)C=C3

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SepimostatFUT-187FUT187FUT 187iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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Sepimostat
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