HIV-1 integrase inhibitor 3
HIV-1 integrase inhibitor 3 is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM.
For research use only. We do not sell to patients.
- CAS No.: 1638504-56-9
- Formula: C21H22F2N4O4
- Molecular Weight:432.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-15592
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Dolutegravir -
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BMS-707035HIV-1 Integrase Strand Transfer Inhibitor -
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Dolutegravir (Standard) -
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HIV-1 integrase inhibitorHIV Inhibitor -
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Raltegravir (Standard)Reference Standard
Biological Activity
Description
IC50 & Target
IC50: 2.7 nM (INST)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HOS | CC50 |
>250 μM
Compound: 6'b
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Cytotoxicity against HOS cells assessed as reduction in cell viability after 48 hrs by ATPLite luminescence assay
Cytotoxicity against HOS cells assessed as reduction in cell viability after 48 hrs by ATPLite luminescence assay
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[PMID: 28737946] |
In Vitro
HIV-1 integrase inhibitor 3 (compound 4c) is a HIV-1 integrase strand transfer (INST) inhibitor with an IC50 of 2.7 nM. HIV-1 integrase inhibitor 3 also displays an antiviral inhibitory potency against the Q148H/G140S mutant with an EC50 of 7 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1638504-56-9
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Molecular Weight 432.42
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Formula C21H22F2N4O4
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SMILES
NC(C1=CC(CCCCCO)=CN=C1N2O)=C(C(NCC3=CC=C(F)C=C3F)=O)C2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HIV-1 integrase inhibitor 3 Related Classifications
HY-108817 Related Classifications
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