Thymidine kinase 1/TK1 Protein, Canine (His)

The thymidine kinase 1/TK1 protein acts as a cell surface receptor in the FCGRT protein. This receptor promotes the transfer of passive humoral immunity from mother to newborn by selectively binding to monomeric immunoglobulin gamma in milk. Thymidine kinase 1/TK1 Protein, Canine (His) is the recombinant canine-derived Thymidine kinase 1/TK1 protein, expressed by E. coli , with C-His labeled tag.

The FCGRT-B2M Heterodimer Protein serves as a cell surface receptor facilitating the transfer of passive humoral immunity from mother to newborn. It selectively binds to the Fc region of monomeric immunoglobulin gamma, particularly in milk, enabling the uptake of IgG at the apical surface of intestinal epithelium. The formed FcRn-IgG complexes are then transcytosed across the epithelium, releasing IgG into blood or tissue fluids. Beyond early life, this receptor plays a crucial role in maintaining effective humoral immunity by recycling IgG and extending its half-life in circulation. The mechanism involves monomeric IgG binding to FcRn in acidic endosomes, leading to the recycling of IgG to the cell surface and subsequent release into the circulation. Notably, FCGRT-B2M Heterodimer also regulates the homeostasis of albumin, the most abundant circulating protein, highlighting its multifaceted role in immune and metabolic processes. The FcRn complex consists of two subunits: p51 and p14, the latter equivalent to beta-2-microglobulin, forming an MHC class I-like heterodimer. Additionally, it interacts with albumin, contributing to the regulation of albumin homeostasis.

Canine

E. coli

C-8*His

E2QXP4 (S2-N242)

/

Full Length of Mature Protein

SCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSNSFSTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFSETMANAGKTVIVAALDGTFQRKAFGTILNLVPLAESVVKLTAVCMECFREAAYTKRLGSEKEVEVIGGADKYHSVCRLCYFKKASGPPMGLDSRENKENVLVLVPGKPGEGKEATGVRKLFAPQHVLQCSPAN

Approximately 25-28 kDa, based on SDS-PAGE under reducing conditions.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.