PD-1/PD-L1-IN-27
PD-1/PD-L1-IN-27 is a potent PD-1/PD-L1 inhibitor with an IC50 value of 134 nM. PD-1/PD-L1-IN-27 shows antitumor effects with low T cell cytotoxicity. PD-1/PD-L1-IN-27 has the ability to activate CD8+ T cells and reduces T cell exhaustion.
For research use only. We do not sell to patients.
- CAS No.: 2891831-47-1
- Formula: C44H35NO6
- Molecular Weight:673.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 134 nM (PD-1/PD-L1)[1]
PD-1/PD-L1-IN-27 (compound MZ58) (2.5, 5, 10, 50 µM; 48 h) shows antitumor effects with low T cell cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells
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Concentration:2.5, 5, 10, 50 µM
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Incubation Time:48 h
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Result:Facilitated cell proliferation with low T cell cytotoxicity.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:20-22 g, 6-8 weeks, male C57BL/6J mice (MC 38 cell lines)[1]
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Dosage:10, 25 mg/kg
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Administration:I.g.
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Result:Showed antitumor effecct.
Chemical Information
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CAS No. 2891831-47-1
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Molecular Weight 673.75
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Formula C44H35NO6
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SMILES
CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC=C(C(OC4=CC(OC5=C4C=CC6=C5C=CC=C6)=O)=C3)CN7CC8=C(C[C@@H]7C(O)=O)C=CC=C8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PD-1/PD-L1-IN-27 Related Classifications
HY-146740 Related Classifications
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