2891831-47-1
Chemical Structure
PD-1/PD-L1-IN-27
- CAS No.: 2891831-47-1
- Formula:C44H35NO6
- Molecular Weight:673.75
IUPAC Name: (R)-2-(4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)-2-((2-oxo-2H-benzo[h]chromen-4-yl)oxy)benzyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
InChIKey: MFFDDZVOAONRQG-LDLOPFEMSA-N
SMILES: CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC=C(C(OC4=CC(OC5=C4C=CC6=C5C=CC=C6)=O)=C3)CN7CC8=C(C[C@@H]7C(O)=O)C=CC=C8
Biological Activity: PD-1/PD-L1-IN-27 is a potent PD-1/PD-L1 inhibitor with an IC50 value of 134 nM. PD-1/PD-L1-IN-27 shows antitumor effects with low T cell cytotoxicity. PD-1/PD-L1-IN-27 has the ability to activate CD8+ T cells and reduces T cell exhaustion[1].
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PD-1/PD-L1-IN-27 | PD-1/PD-L1-IN-27 is a potent PD-1/PD-L1 inhibitor with an IC50 value of 134 nM. PD-1/PD-L1-IN-27 shows antitumor effects with low T cell cytotoxicity. PD-1/PD-L1-IN-27 has the ability to activate CD8+ T cells and reduces T cell exhaustion. | |||||||||||||||||||||
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Keywords
