GLS1 Inhibitor-3
GLS1 Inhibitor-3 (compound C147) is a potent GLS1 inhibitor with an IC50 of 27.98 nM. GLS1 Inhibitor-3 shows antiproliferative activity.
For research use only. We do not sell to patients.
- CAS No.: 2435781-94-3
- Formula: C30H32N10O2S
- Molecular Weight:596.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 27.98 nM (GLS1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.15 μM
Compound: C147
|
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 31603674] |
| HCT-116 | IC50 |
0.15 μM
Compound: C147
|
Antiproliferative activity against human HCT-116 cells overexpressing GLS1 assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells overexpressing GLS1 assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
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[PMID: 35428013] |
| MDA-MB-436 | IC50 |
0.18 μM
Compound: C147
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Antiproliferative activity against human MDA-MB-436 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-436 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
|
[PMID: 31603674] |
| MDA-MB-436 | IC50 |
0.18 μM
Compound: C147
|
Antiproliferative activity against human MDA-MB-436 cells overexpressing GLS1 assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-436 cells overexpressing GLS1 assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
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[PMID: 35428013] |
Chemical Information
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CAS No. 2435781-94-3
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Molecular Weight 596.71
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Formula C30H32N10O2S
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SMILES
CC1=CC=C(C=C1)CN2C=C(N=N2)CCC(NC3=CC=C(N=N3)CCCCC4=NN=C(S4)NC(CC5=NC=CC=C5)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GLS1 Inhibitor-3 Related Classifications
HY-146616 Related Classifications
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